ReviewAnnals of the New York Academy of Sciences2010
Inhibition of inflammation and carcinogenesis in the lung and colon by tocopherols.
Review in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Pre- and post-treatment of α-Tocopherol on cognitive, synaptic plasticity, and mitochondrial disorders of the hippocampus in icv-streptozotocin-induced sporadic Alzheimer's-like disease in male Wistar rat.Frontiers in neuroscience · 2023Article
- Characterization and Effect of Refining on the Oil Extracted from Durum Wheat By-Products.Foods (Basel, Switzerland) · 2022Article
- Administration of vitamin E attenuates airway inflammation through restoration of Nrf2 in a mouse model of asthma.Journal of cellular and molecular medicine · 2021Article
- Vitamin E Phosphate Coating Stimulates Bone Deposition in Implant-related Infections in a Rat Model.Clinical orthopaedics and related research · 2018Article
- Chronic diseases, inflammation, and spices: how are they linked?Journal of translational medicine · 2018Review
- Alpha-tocopherol ameliorates experimental autoimmune encephalomyelitis through the regulation of Th1 cells.Iranian journal of basic medical sciences · 2016Article
- Vitamin E: Curse or Benefit in Alzheimer's Disease? A Systematic Investigation of the Impact of α-, γ- and δ-Tocopherol on Aß Generation and Degradation in Neuroblastoma Cells.The journal of nutrition, health & aging · 2015Article
- Studies on the nutraceuticals composition of wheat derived oils wheat bran oil and wheat germ oil.Journal of food science and technology · 2015Article
- The anti-inflammatory role of vitamin e in prevention of osteoporosis.Advances in pharmacological sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Tocopherols, which exist in alpha, beta, gamma, and delta forms, are antioxidative nutrients also known as vitamin E. Although alpha-tocopherol (alpha-T) is the major form of vitamin E found in the blood and tissues, gamma- and delta-T have been suggested to have stronger anti-inflammatory activities. In the present study, using a tocopherol mixture that is rich in gamma-T (gamma-TmT, which contains 57%gamma-T), we demonstrated the inhibition of inflammation as well as of cancer formation and growth in the lung and colon in animal models. When given in the diet at 0.3%, gamma-TmT inhibited chemically induced lung tumorigenesis in the A/J mice as well as the growth of human lung cancer cell H1299 xenograft tumors. gamma-TmT also decreased the levels of 8-hydroxydeoxyguanosine, gamma-H2AX, and nitrotyrosine in tumors. More evident anti-inflammatory and cancer preventive activities of dietary gamma-TmT were demonstrated in mice treated with azoxymethane and dextran sulfate sodium. These results demonstrate the antioxidative, anti-inflammatory, and anticarcinogenic activities of tocopherols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.