ArticleAnnals of the New York Academy of Sciences2010
Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model.
Article in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 79 citations in OpenAlex.
- Cellular defense mechanisms against asbestos fibers.Frontiers in public health · 2025Review
- Prognostic factors and the prognostic role of inflammation indices in malignant pleural mesothelioma.Turk gogus kalp damar cerrahisi dergisi · 2023Article
- Article
- Review
- Mouse models for mesothelioma drug discovery and development.Expert opinion on drug discovery · 2021Review
- Malignant mesothelioma metastatic to the oral region and latest topics (Review).Molecular and clinical oncology · 2020Review
- Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Scientific Advances and New Frontiers in Mesothelioma Therapeutics.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2018Review
- HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome.Oncogene · 2018Article
- Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma.Oncogene · 2017Article
- The Cappadocia mesothelioma epidemic: its influence in Turkey and abroad.Annals of translational medicine · 2017Review
- Mesothelioma: recent highlights.Annals of translational medicine · 2017Review
- HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma.Oncotarget · 2017Article
- FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model.Journal of translational medicine · 2017Article
- Asbestos-Induced Mesothelial to Fibroblastic Transition Is Modulated by the Inflammasome.The American journal of pathology · 2017Article
- The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages.Oxidative medicine and cellular longevity · 2017Article
- The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases.Particle and fibre toxicology · 2016Review
- Prognostic value of the lymphocyte-to-monocyte ratio and other inflammatory markers in malignant pleural mesothelioma.Environmental health and preventive medicine · 2016Article
- The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells.Oncology letters · 2016Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Asbestos fibers cause chronic inflammation that may be critical to the development of malignant mesothelioma (MM). Two human MM cell lines (Hmeso, PPM Mill) were used in a SCID mouse xenograft model to assess time-dependent patterns of inflammation and tumor formation. After intraperitoneal (IP) injection of MM cells, mice were euthanized at 7, 14, and 30 days, and peritoneal lavage fluid (PLF) was examined for immune cell profiles and human and mouse cytokines. Increases in human MM-derived IL-6, IL-8, bFGF, and VEGF were observed in mice at 7 days postinjection of either MM line, and a striking neutrophilia was observed at all time points. Free-floating tumor spheroids developed in mice at 14 days, and both spheroids and adherent MM tumor masses occurred in all mice at 30 days. Results suggest that inflammation and cytokine production precede and may be critical to the development of MMs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.