Evidence map›Paper›PMID 20716125›Full record

ArticleJournal of cellular and molecular medicine2010

Telocytes in endocardium: electron microscope evidence.

Mihaela Gherghiceanu, C G Manole, L M Popescu

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 135 citations in OpenAlex.

  1. Review
  2. Young cardiac telocyte-derived exosomes rejuvenate aging hearts in rats.Frontiers in cell and developmental biology · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Dermal Microvascular Units in Domestic Pigs (Frontiers in veterinary science · 2022
    Article
  9. Telocytes: Active Players in the Rainbow Trout (Animals : an open access journal from MDPI · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Telocytes in the Normal and Pathological Peripheral Nervous System.International journal of molecular sciences · 2020
    Review
  16. Cardiac telocytes exist in the adult Xenopus tropicalis heart.Journal of cellular and molecular medicine · 2020
    Article
  17. Emerging diverse roles of telocytes.Development (Cambridge, England) · 2019
    Review
  18. Article
  19. Review
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mihaela GherghiceanuVictor Babeüs National Institute of Pathology, Bucharest, Romania.
C G Manole
L M Popescu
Carol Davila University of Medicine and Pharmacy · ROInstitutul National Victor Babes · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term TELOCYTES was very recently introduced, for replacing the name Interstitial Cajal-Like Cells (ICLC). In fact, telocytes are not really Cajal-like cells, they being different from all other interstitial cells by the presence of telopodes, which are cell-body prolongations, very thin (under the resolving power of light microscopy), extremely long (tens up to hundreds of micrometers), with a moniliform aspect (many dilations along), and having caveolae. The presence of telocytes in epicardium and myocardium was previously documented. We present here electron microscope images showing the existence of telocytes, with telopodes, at the level of mouse endocardium. Telocytes are located in the subendothelial layer of endocardium, and their telopodes are interposed in between the endocardial endothelium and the cardiomyocytes bundles. Some telopodes penetrate from the endocardium among the cardiomyocytes and surround them, eventually. Telopodes frequently establish close spatial relationships with myocardial blood capillaries and nerve endings. Because we may consider endocardium as a 'blood-heart barrier', or more exactly as a 'blood-myocardium barrier', telocytes might have an important role in such a barrier being the dominant cell population in subendothelial layer of endocardium.

Indexed as

Microscopy, ElectronAnimalsEndocardiumHeart AtriaHeart VentriclesInterstitial Cells of CajalMice

Identifiers

PMID20716125
PMCPMC3822573
OpenAlexW2026539029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.