ReviewExpert opinion on drug delivery2010
Zinc oxide nanoparticles for selective destruction of tumor cells and potential for drug delivery applications.
Review in Expert opinion on drug delivery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 286 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
286 citing papers in PubMed, 1,282 citations in OpenAlex.
- Zinc Oxide Nanoparticles as Drug Delivery Tools.Materials (Basel, Switzerland) · 2026Review
- Zinc Oxide/Ag Water-Gated Field-Effect Transistor Coupled with Surface-Enhanced Raman Scattering for Indigo Dye Detection.ACS omega · 2026Article
- Ameliorative Effect of Green Bimetallic Zinc Oxide-Magnesium Oxide Nanoparticles Against Gastric Ulcer in Rats via Modulation of Oxidative Stress, Inflammatory Cascades, Nrf2/NF-κB Signaling, Angiogenic VEGF Expression.Biological trace element research · 2026Article
- Green-SynthesizedBiomimetics (Basel, Switzerland) · 2026Article
- A novel therapeutic strategy against gastric carcinoma: artemisia sieberi-derived biogenic zno nanoparticles inducing intrinsic apoptosis and suppressing AGS cell proliferation.Scientific reports · 2026Article
- Dose-dependent effects of zinc oxide nanoparticles on pre-osteoblast cellular response.Scientific reports · 2026Article
- Tuning Anticancer Activity and Antimicrobial Response of ZnO Nanoparticles Through Halogenosilane Surface Modification.International journal of molecular sciences · 2026Article
- Antimicrobial Systems Based on Essential Oils Advanced by Zinc Oxide Nanoparticles.ACS pharmacology & translational science · 2026Review
- Evaluating the mechanisms and therapeutic potential of ZnO nanoparticles as selective anticancer agents for lung malignancies.Discover nano · 2026Review
- In Vitro and In Vivo Study of Green-Synthesized Zinc Oxide Nanoparticles as a Novel Anticoccidial Agent.Acta parasitologica · 2026Article
- Light-triggered drug release via fiber optic heater-integrated with thermoresponsive microgels for locoregional cancer therapy.Scientific reports · 2026Article
- Anticancer potential of radioactively activated zinc: mechanisms and therapeutic applications.Scientific reports · 2026Article
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- Advances of Green-Synthesized Nanoparticles for Biomedical Applications.BioMed research international · 2026Review
- Green-synthesized ZnO-MnO nanocomposite as a potent antimicrobial and antibiofilm agent: protein leakage mechanism and synergistic interaction with cefotaxime.Frontiers in microbiology · 2026Article
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- Advancing Lung Cancer Treatment: A Comprehensive Review of Photodynamic Therapy and Nanoparticle Applications.Pharmaceutics · 2025Review
- Zinc nanoparticles mitigate azoxystrobin and its nanoencapsulation-induced hepatic and renal toxicity in rats.Redox report : communications in free radical research · 2025Article
- Improved photocatalytic activity and enhanced germination rate ofRSC advances · 2025Article
226 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
importance of the fieldMetal oxide nanoparticles, including zinc oxide, are versatile platforms for biomedical applications and therapeutic intervention. There is an urgent need to develop new classes of anticancer agents, and recent studies demonstrate that ZnO nanomaterials hold considerable promise. AREAS COVERED IN THIS REVIEW: This review analyzes the biomedical applications of metal oxide and ZnO nanomaterials under development at the experimental, preclinical and clinical levels. A discussion regarding the advantages, approaches and limitations surrounding the use of metal oxide nanoparticles for cancer applications and drug delivery is presented. The scope of this article is focused on ZnO, and other metal oxide nanomaterial systems, and their proposed mechanisms of cytotoxic action, as well as current approaches to improve their targeting and cytotoxicity against cancer cells. WHAT THE READER WILL GAIN: This review aims to give an overview of ZnO nanomaterials in biomedical applications. TAKE HOME MESSAGE: Through a better understanding of the mechanisms of action and cellular consequences resulting from nanoparticles interactions with cells, the inherent toxicity and selectivity of ZnO nanoparticles against cancer may be improved further to make them attractive new anticancer agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.