Evidence map›Paper›PMID 20714831›Full record

ReviewCurrent HIV/AIDS reports2010

Readiness: the state of the science (or the lack thereof).

Richard M Grimes, Deanna E Grimes

Registry-linked trialAbstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02459678 (ART Readiness in HIV-infected Pregnant Women), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02459678 nacompletednot on this mapstarted 2015, after this paper: background citation

ART Readiness in HIV-infected Pregnant Women: From Formative Qualitative Research to Individual Randomized Trial

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2015 to 2018Enrolled454ConditionsHuman Immunodeficiency VirusArmsEnhanced Adherence Package, Standard of Care
3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Immediate Antiretroviral Therapy: The Need for a Health Equity Approach.International journal of environmental research and public health · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Richard M GrimesDivision of General Medicine, Department of Medicine, Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA. Richard.M.Grimes@uth.tmc.edu
Deanna E Grimes

Funding

Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI BUTEL, JANET S · 1994 to 2015
$21.7M
NIAID NIH HHS AI036211NIAID NIH HHS P30 AI036211
6 · The paper itself

Abstract

HIV treatment guidelines state that patients' readiness should be assessed before initiating highly active antiretroviral therapy (HAART) to assure adherence. None of the guidelines provide a way to measure readiness. Therefore, this article sought to review the literature on readiness to determine if there was a viable predictor of adherence. Twenty-seven articles were reviewed. Nine described studies that examined the relationship between a measure of readiness and HAART adherence. No readiness measure demonstrated clinical utility as a predictor of adherence. Study flaws included small sample sizes (only one study >100 patients), short follow-up periods (all ≤1 year and six were ≤5 months, four ≤1 month), measures of readiness that related poorly to adherence, and inconsistent adherence measures (eight different measures were used by the researchers). Neither the guidelines nor the literature will help clinicians judge who should initiate HAART and who should delay treatment.

Indexed as

Treatment RefusalAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountClinical ProtocolsHealth BehaviorHealth Knowledge, Attitudes, PracticeHIVHIV InfectionsHumansMedication AdherencePatient Acceptance of Health CarePatient ParticipationPractice Guidelines as TopicAnti-HIV Agents

Identifiers

PMID20714831
PMCPMC2989238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.