ReviewChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2011
Non-specific (entropic) forces as major determinants of the structure of mammalian chromosomes.
Review in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Helical coiling of metaphase chromatids.Nucleic acids research · 2023Article
- Consistencies and contradictions in different polymer models of chromatin architecture.Computational and structural biotechnology journal · 2023Review
- Epigenetic-structural changes in X chromosomes promote Xic pairing during early differentiation of mouse embryonic stem cells.Biophysics and physicobiology · 2022Article
- Mathematical model of chromosomal dynamics during DNA double strand break repair in budding yeast.Biophysics and physicobiology · 2022Article
- Mesoscale Modeling of Nucleosome-Binding Antibody PL2-6: Mono- versus Bivalent Chromatin Complexes.Biophysical journal · 2020Article
- DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture?International journal of molecular sciences · 2018Review
- A new application of the phase-field method for understanding the mechanisms of nuclear architecture reorganization.Journal of mathematical biology · 2017Article
- Quantified effects of chromosome-nuclear envelope attachments on 3D organization of chromosomes.Nucleus (Austin, Tex.) · 2015Article
- Macromolecular crowding as a regulator of gene transcription.Biophysical journal · 2014Article
- DNA double-strand breaks: linking gene expression to chromosome morphology and mobility.Chromosoma · 2014Article
- Investigation of the chromosome regions with significant affinity for the nuclear envelope in fruit fly--a model based approach.PloS one · 2014Article
- Centromere tethering confines chromosome domains.Molecular cell · 2013Article
- Review series: The functions and consequences of force at kinetochores.The Journal of cell biology · 2013Review
- Centromeres: unique chromatin structures that drive chromosome segregation.Nature reviews. Molecular cell biology · 2011Review
- Dynamic as well as stable protein interactions contribute to genome function and maintenance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Four specific forces (H-bonds, van der Waals forces, hydrophobic and charge interactions) shape the structure of proteins, and many biologists assume they will determine the shape of all structures in the cell. However, as the mass and contour length of a human chromosome are ~7 orders of magnitude larger than those of a typical protein, additional forces can become significant. We review evidence that additional non-specific (entropic) forces are major determinants of chromosomal shape and position. They are sufficient to drive the segregation (de-mixing) of newly replicated DNA to the poles of bacterial cells, while an entropic centrifuge can both form human chromosomes into territories and position them appropriately in nuclei; more locally, a depletion attraction can loop bacterial and human genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.