ArticleGenetica2011
Novel female-specific splice form of dsx in the silkworm, Bombyx mori.
Article in Genetica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- CRISPR/Cas9 mediated sex-ratio distortion by sex specific gene editing inSaudi journal of biological sciences · 2022Article
- Self-limiting fall armyworm: a new approach in development for sustainable crop protection and resistance management.BMC biotechnology · 2022Article
- A conserved role of the duplicated Masculinizer gene in sex determination of the Mediterranean flour moth, Ephestia kuehniella.PLoS genetics · 2021Article
- The C-terminus of DSX(F5) protein acts as a novel regulatory domain in Bombyx mori.Transgenic research · 2016Article
- Double nexus--Doublesex is the connecting element in sex determination.Briefings in functional genomics · 2015Review
- Identification of the key stages for sex determination in the silkworm, Bombyx mori.Development genes and evolution · 2014Article
- Transgene-based, female-specific lethality system for genetic sexing of the silkworm, Bombyx mori.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Sex determination strategies in 2012: towards a common regulatory model?Reproductive biology and endocrinology : RB&E · 2012Review
- Doublesex target genes in the red flour beetle, Tribolium castaneum.Scientific reports · 2012Article
- Sex determination in beetles: production of all male progeny by parental RNAi knockdown of transformer.Scientific reports · 2012Article
- Doublesex: a conserved downstream gene controlled by diverse upstream regulators.Journal of genetics · 2010Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Bombyx mori doublesex (Bmdsx), a homologue of doublesex of Drosophila, is the bottom most gene of the sex determination cascade. Bmdsx plays a very crucial role in somatic sexual development. Its pre-mRNA sex-specifically splices to generate two splice variants; one encodes female-specific and the other encodes male-specific polypeptides which differ only at their C-termini. The open reading frame of Bmdsx consists of 5 exons, of which exons 3 and 4 are female-specific and are skipped in males. In the present study, we have identified a third splice form of the Bmdsx which is specific only to females and differs from the previously reported Bmdsxf isoform by the presence of 15 bp sequence. This new female splice form is generated as a result of alternative 5' splice site selection in the third exon adding additional 15 bp sequence in exon 3 which results in alteration of the reading frame leading to incorporation of an early stop codon. Thus the protein encoded by this splice form is 20 aa shorter than the known BmDsxF. Initial results obtained from the study of dsx homologues in Saturniid silkmoths suggest that both the female-specific Dsx proteins are essential for female sexual differentiation. It remains to be seen whether female-specific multiple splice forms of dsx are characteristic feature of only silkmoths or widespread among lepidopterans. The findings that sex determination mechanism is unique in lepidopterans offer an opportunity to develop genetic sexing methods in beneficial as well as economically destructive lepidopteran pests.
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