ArticleHuman genetics2010
IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians.
Article in Human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Interferon Gamma +874T/A Polymorphism Increases the Risk of Hepatitis Virus-Related Diseases: Evidence from a Meta-Analysis.PloS one · 2015Pooled it
- Human Genetic Susceptibility of Leprosy Recurrence.Scientific reports · 2020Trial
- Functional single nucleotide polymorphisms in CACNA2D3 and other autophagy-related genes are associated with leprosy among Brazilians.PLoS neglected tropical diseases · 2026Article
- Leprosy.Nature reviews. Disease primers · 2024Review
- Leprosy: treatment, prevention, immune response and gene function.Frontiers in immunology · 2024Review
- Association of CD209 (DC-SIGN) rs735240 SNV with paucibacillary leprosy in the Brazilian population and its functional effects.Memorias do Instituto Oswaldo Cruz · 2022Article
- Increased oxidative stress in elderly leprosy patients is related to age but not to bacillary load.PLoS neglected tropical diseases · 2021Article
- Associations Between the Purinergic Receptor P2X7 and Leprosy Disease.Frontiers in genetics · 2021Article
- Association of NOD2 and IFNG single nucleotide polymorphisms with leprosy in the Amazon ethnic admixed population.PLoS neglected tropical diseases · 2020Article
- Advances in the Immunology and Genetics of Leprosy.Frontiers in immunology · 2020Review
- Article
- Genetic polymorphisms of the IL6 and NOD2 genes are risk factors for inflammatory reactions in leprosy.PLoS neglected tropical diseases · 2017Article
- Subsets of Inflammatory Cytokine Gene Polymorphisms are Associated with Risk of Carcinogenic Liver FlukeThe Korean journal of parasitology · 2017Article
- Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China.Genes and immunity · 2015Article
- IL10A genotypic association with decreased IL-10 circulating levels in malaria infected individuals from endemic area of the Brazilian Amazon.Malaria journal · 2015Article
- Interferon gamma polymorphisms and hepatitis B virus-related liver cirrhosis risk in a Chinese population.Cancer cell international · 2015Article
- Gene polymorphisms in patients with pulmonary tuberculosis from Mozambique.Molecular biology reports · 2015Article
- Gene Association with Leprosy: A Review of Published Data.Frontiers in immunology · 2015Review
- Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leprosy is a chronic infectious disease caused by Mycobacterium leprae, a low virulence mycobacterium, and the outcome of disease is dependent on the host genetics for either susceptibility per se or severity. The IFNG gene codes for interferon-γ (IFN-γ), a cytokine that plays a key role in host defense against intracellular pathogens. Indeed, single nucleotide polymorphisms (SNPs) in IFNG have been evaluated in several genetic epidemiological studies, and the SNP +874T>A, the +874T allele, more specifically, has been associated with protection against infectious diseases, especially tuberculosis. Here, we evaluated the association of the IFNG locus with leprosy enrolling 2,125 Brazilian subjects. First, we conducted a case-control study with subjects recruited from the state of São Paulo, using the +874 T>A (rs2430561), +2109 A>G (rs1861494) and rs2069727 SNPs. Then, a second study including 1,370 individuals from Rio de Janeiro was conducted. Results of the case-control studies have shown a protective effect for +874T carriers (OR(adjusted) = 0.75; p = 0.005 for both studies combined), which was corroborated when these studies were compared with literature data. No association was found between the SNP +874T>A and the quantitative Mitsuda response. Nevertheless, the spontaneous IFN-γ release by peripheral blood mononuclear cells was higher among +874T carriers. The results shown here along with a previously reported meta-analysis of tuberculosis studies indicate that the SNP +874T>A plays a role in resistance to mycobacterial diseases.
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Registered trials
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