ArticleInternational journal of biological sciences2010
Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression.
Article in International journal of biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Inverse Association of p63 Expression with Hormone Receptor Status in Invasive Breast Cancer.Journal of personalized medicine · 2026Article
- Involvement ofFrontiers in cell and developmental biology · 2024Article
- The most likely but largely ignored triggering factor for breast (or all) cancer invasion.Journal of Cancer · 2023Article
- Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases.Molecules (Basel, Switzerland) · 2022Review
- The TP63 Gene Polymorphism rs17506395 is Associated with Early Breast Cancer in Cameroon.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- p63 Expression and its Relation to Epithelial Cells Proliferation in Dentigerous Cyst, Odontogenic Keratocyst, and Ameloblastoma.Pathology oncology research : POR · 2020Article
- Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype.Frontiers in oncology · 2020Review
- TGF-β1 stimulates epithelial-mesenchymal transition and cancer-associated myoepithelial cell during the progression from in situ to invasive breast cancer.Cancer cell international · 2019Article
- Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine.The EPMA journal · 2018Review
- Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis.International journal of biological sciences · 2017Review
- Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.Journal of cancer research and clinical oncology · 2015Article
- Quantitative assessment of the influence of TP63 gene polymorphisms and lung cancer risk: evidence based on 93,751 subjects.PloS one · 2014Article
- Genomic signatures of pregnancy-associated breast cancer epithelia and stroma and their regulation by estrogens and progesterone.Hormones & cancer · 2013Article
- Destructive impact of T-lymphocytes, NK and Mast cells on basal cell layers: implications for tumor invasion.BMC cancer · 2013Article
- Biomarkers in an animal model for revealing neural, hematologic, and behavioral correlates of PTSD.Journal of visualized experiments : JoVE · 2012Article
- Tube-like structures with co-expression of D2-40 and CD34: newly formed vasculatures?International journal of biological sciences · 2012Article
- Rat mitochondrion-neuron focused microarray (rMNChip) and bioinformatics tools for rapid identification of differential pathways in brain tissues.International journal of biological sciences · 2011Article
- miR-21 Expression in Pregnancy-Associated Breast Cancer: A Possible Marker of Poor Prognosis.Journal of Cancer · 2011Article
- The myoepithelial cell layer may serve as a potential trigger factor for different outcomes of stage-matched invasive lobular and ductal breast cancers.International journal of biological sciences · 2011Article
- In situ malignant transformation and progenitor-mediated cell budding: two different pathways for breast ductal and lobular tumor invasion.Journal of Cancer · 2011Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Our previous studies revealed that pregnancy associated breast cancer (PABC) had significantly reduced nuclear p63 expression in myoepithelia, while intense cytoplasmic p63 expression in associated epithelia. Our current study assessed these epithelia using immunohistochemistry with a panel of aggressiveness and invasiveness related markers and comparative genomic hybridization (array-CGH) with over 30,000 DNA probes. These epithelia showed several unique alterations, including (1) immunohistochemical and morphological resemblance to invasive cancer, (2) significant gain in copy numbers of DNA coding genes for morphogenesis, angiogenesis, and metastasis, and (3) significant loss in copy numbers of DNA coding genes for tumor suppressors, cell adhesion, and macromolecular complex assembly or intra-cellular trafficking. Detected array-CGH alterations correlated well with in vivo expression of a number of corresponding proteins tested. These findings suggest that aberrant sub-cellular localization of p63 expression in normal or hyperplastic appearing epithelial cells may significant contribute to increased invasiveness and aggressiveness of these cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.