ArticleMarine drugs2010
Bromopyrrole alkaloids as lead compounds against protozoan parasites.
Article in Marine drugs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 120 citations in OpenAlex.
- Biofouling inhibition by Staphylococcus aureus extracts and their potential use for paints.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Secondary metabolites from marine sponges of the genusRSC advances · 2022Review
- Promising antiparasitic agents from marine sponges.Saudi journal of biological sciences · 2022Review
- Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria.Natural product reports · 2021Review
- Antibiofilm and Anti-Candidal Activities of the Extract of the Marine Sponge Agelas dispar.Mycopathologia · 2021Article
- Marine Pyrrole Alkaloids.Marine drugs · 2021Review
- Bioprospecting marine actinomycetes for antileishmanial drugs: current perspectives and future prospects.Heliyon · 2021Review
- Study of the Antimalarial Activity of the Leaf Extracts and Fractions ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- The preparation of (4H)-imidazol-4-ones and their application in the total synthesis of natural products.Organic chemistry frontiers : an international journal of organic chemistry · 2020Article
- In Vitro and In Vivo Assessment of the Efficacy of Bromoageliferin, an Alkaloid Isolated from the SpongeMarine drugs · 2020Article
- Antiplasmodial natural products: an update.Malaria journal · 2019Review
- Sustainable Elimination (Zero Cases) of Sleeping Sickness: How Far Are We from Achieving This Goal?Pathogens (Basel, Switzerland) · 2019Review
- Synthesis of Multi-Substituted Pyrrole Derivatives Through [3+2] Cycloaddition with Tosylmethyl Isocyanides (TosMICs) and Electron-Deficient Compounds.Molecules (Basel, Switzerland) · 2018Review
- Microbial and Functional Biodiversity Patterns in Sponges that Accumulate Bromopyrrole Alkaloids Suggest Horizontal Gene Transfer of Halogenase Genes.Microbial ecology · 2018Article
- Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.Journal of natural products · 2018Article
- The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases.Molecules (Basel, Switzerland) · 2016Review
- A coralline algal-associated bacterium, pseudoalteromonas strain J010, yields five new korormicins and a bromopyrrole.Marine drugs · 2014Article
- Antimicrobial activity of the marine alkaloids, clathrodin and oroidin, and their synthetic analogues.Marine drugs · 2014Article
- Trypanocidal activity of marine natural products.Marine drugs · 2013Review
- Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity.Marine drugs · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking the imidazole ring bromoaldisin (7), longamide B (8) and longamide A (9), the dimeric oroidin derivatives sceptrin (10) and dibromopalau'amine (11), and the non-oroidin bromopyrrolohomoarginin (12), manzacidin A (13), and agelongine (14), obtained from marine sponges belonging to Axinella and Agelas genera have been screened in vitro against four parasitic protozoa, i.e., two Trypanosoma species (T. brucei rhodesiense and T. cruzi), Leishmania donovani and Plasmodium falciparum (K1 strain, a chloroquine resistant strain), responsible of human diseases with high morbidity and, in the case of malaria, high mortality. Our results indicate longamide B (8) and dibromopalau'amine (11) to be promising trypanocidal and antileishmanial agents, while dispacamide B (3) and spongiacidin B (6) emerge as antimalarial lead compounds. In addition, evaluation of the activity of the test alkaloids (2-14) against three different enzymes (PfFabI, PfFabG, PfFabZ) involved in the de novo fatty acid biosynthesis pathway of P. falciparum (PfFAS-II) identified bromopyrrolohomoarginin (12) as a potent inhibitor of PfFabZ. The structural similarity within the series of tested molecules allowed us to draw some preliminary structure-activity relationships. Tests against the mammalian L6 cells revealed important clues on therapeutic index of the metabolites. This is the first detailed study on the antiprotozoal potential of marine bromopyrrole alkaloids.
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