ArticleCommunicative & integrative biology2010
Roles of membrane trafficking in nerve repair and regeneration.
Article in Communicative & integrative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Wound Repair of the Cell Membrane: Lessons fromCells · 2024Review
- The Role of Spastin in Axon Biology.Frontiers in cell and developmental biology · 2022Review
- Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury.International journal of molecular sciences · 2021Review
- Mitochondrial Behavior in Axon Degeneration and Regeneration.Frontiers in aging neuroscience · 2021Review
- Molecular signature of different lesion types in the brain white matter of patients with progressive multiple sclerosis.Acta neuropathologica communications · 2019Article
- Association of Serum Cholesterol Levels With Peripheral Nerve Damage in Patients With Type 2 Diabetes.JAMA network open · 2019Observational
- Intrinsic mechanisms of neuronal axon regeneration.Nature reviews. Neuroscience · 2018Review
- SNARE complex in axonal guidance and neuroregeneration.Neural regeneration research · 2018Review
- FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Signaling Over Distances.Molecular & cellular proteomics : MCP · 2016Review
- Release of calcium from endolysosomes increases calcium influx through N-type calcium channels: Evidence for acidic store-operated calcium entry in neurons.Cell calcium · 2015Article
- Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences.Frontiers in neuroscience · 2015Review
- Article
- Axon injury and regeneration in the adult Drosophila.Scientific reports · 2014Article
- Mechanisms of neuronal membrane sealing following mechanical trauma.Neuroscience bulletin · 2014Review
- Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration.The Journal of biological chemistry · 2014Article
- Raf-1, actin dynamics, and abelson tyrosine kinase in human airway smooth muscle cells.American journal of respiratory cell and molecular biology · 2013Article
- Efficient retrograde transport of pseudorabies virus within neurons requires local protein synthesis in axons.Cell host & microbe · 2013Article
- Axon regeneration mechanisms: insights from C. elegans.Trends in cell biology · 2011Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Successful axonal repair following injury is critical for nerve regeneration and functional recovery. Nerve repair relies on three functionally distinct events involving membrane trafficking. First, axonally transported vesicles accumulate, while others are generated at the cut end to restore a selective barrier to the severed axon. Then, retrograde transport of vesicles along microtubules informs the cell body that damage has occurred in the distal axon. Finally, membrane addition to a newly formed growth cone, or to the axonal membrane is required to promote axonal re-growth and elongation. Yet, how these membrane trafficking events are regulated and what are the identities of the molecules and organelles involved remains largely unknown. Several potential factors have been recently identified. Members of the SNARE machinery appear to regulate fusion of vesicles in a calcium-dependent manner to promote axolemmal resealing. Retrograde transport of endosomes powered by the dynein-dynactin molecular motor complex represents a potential injury-signaling platform. Several classes of secretory and endocytic vesicles may coordinate axonal membrane extension and re-growth. Here we discuss recent advances in understanding the mechanisms of the membrane trafficking involved in nerve repair.
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Registered trials
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