ReviewInternational journal of chronic obstructive pulmonary disease2010
An overview of the benefits and drawbacks of inhaled corticosteroids in chronic obstructive pulmonary disease.
Review in International journal of chronic obstructive pulmonary disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Long-acting inhaled therapy (beta-agonists, anticholinergics and steroids) for COPD: a network meta-analysis.The Cochrane database of systematic reviews · 2014Pooled it
- Combined corticosteroid and long-acting beta(2)-agonist in one inhaler versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2012Pooled it
- Inhaled corticosteroids versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2011Pooled it
- The effect of adding inhaled corticosteroids to tiotropium and long-acting beta(2)-agonists for chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2011Pooled it
- Concomitant inhaled corticosteroid use and the risk of pneumonia in COPD: a matched-subgroup post hoc analysis of the UPLIFT® trial.Respiratory research · 2018Trial
- Trial
- LANTERN: a randomized study of QVA149 versus salmeterol/fluticasone combination in patients with COPD.International journal of chronic obstructive pulmonary disease · 2015Trial
- The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations.BMC medicine · 2026Article
- Initiating Low-Value Inhaled Corticosteroids in an Inception Cohort with Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2020Article
- Effect of Inhaled Corticosteroid Withdrawal on Chronic Obstructive Pulmonary Disease Exacerbations in Patients Taking Triple Therapy at Baseline.International journal of chronic obstructive pulmonary disease · 2020Article
- Vitamin D should be supplemented more actively in elderly patients with coronary heart disease combined with COPD.International journal of chronic obstructive pulmonary disease · 2016Article
- Outcome of Inhaler Withdrawal in Patients Receiving Triple Therapy for COPD.Tuberculosis and respiratory diseases · 2016Article
- Optimizing Treatment of Elderly COPD Patients: What Role for Inhaled Corticosteroids?Drugs & aging · 2015Review
- Self-reported osteoporosis prevention in inhaled corticosteroid users in community pharmacy setting.SAGE open medicine · 2015Article
- Inhaled corticosteroids in chronic obstructive pulmonary disease: a pro-con perspective.British journal of clinical pharmacology · 2014Review
- Review
- Role of infections.Clinics in chest medicine · 2014Review
- The pharmacological approach to the elderly COPD patient.Drugs & aging · 2013Review
- Overtreatment of COPD with inhaled corticosteroids--implications for safety and costs: cross-sectional observational study.PloS one · 2013Observational
- Inhaled corticosteroid use in patients with chronic obstructive pulmonary disease and the risk of pneumonia: a retrospective claims data analysis.International journal of chronic obstructive pulmonary disease · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe benefit harm profile of inhaled corticosteroids, and their effect on patient oriented outcomes and comorbid pneumonia, osteoporosis and cardiovascular disease in patients with chronic obstructive pulmonary disease remain uncertain.
methodsAn overview of the evidence on the risks and benefits of inhaled corticosteroids (fluticasone and budesonide) in chronic obstructive pulmonary disease from recent randomized controlled trials and systematic reviews. Observational studies on adverse effects were also evaluated.
resultsEvidence from recent meta-analysis suggests a modest benefit from inhaled corticosteroid long-acting beta-agonist combination inhalers on the frequency of exacerbations, (rate ratio [RR], 0.82; 95% confidence interval [CI]: 0.78 to 0.88), in improvements in quality of life measures, and forced expiratory volume in one second when compared to long-acting beta-agonists alone. On the outcome of pneumonia, our updated meta-analysis of trials (n = 24 trials; RR, 1.56; 95% CI: 1.40-1.74, P < 0.0001) and observational studies (n = 4 studies; RR, 1.44; 95% CI: 1.20-1.75, P = 0.0001) shows a significant increase in the risk of pneumonia with the inhaled corticosteroids currently available (fluticasone and budesonide). Evidence for any intraclass differences in the risk of pneumonia between currently available formulations is inconclusive due to the absence of head to head trials. Inhaled corticosteroids have no cardiovascular effects.
conclusionsAmong patients with chronic obstructive pulmonary disease, clinicians should carefully balance these long-term risks of inhaled corticosteroid against their symptomatic benefits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.