ArticleClinical ophthalmology (Auckland, N.Z.)2010
The controversy over the association between statins use and progression of age-related macular degeneration: a mini review.
Article in Clinical ophthalmology (Auckland, N.Z.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Association between Antihyperlipidemic Agent Use and Age-Related Macular Degeneration in Patients with Hyperlipidemia: A Population-Based Retrospective Cohort Study.Biomedicines · 2023Article
- Relationships between Lipid-Related Metabolites and Age-Related Macular Degeneration Vary with Complement Genotype.Ophthalmology science · 2022Article
- Statins and the progression of age-related macular degeneration in the United States.PloS one · 2021Article
- Macular xanthophylls, lipoprotein-related genes, and age-related macular degeneration.The American journal of clinical nutrition · 2014Review
- Age-related macular degeneration and protective effect of HMG Co-A reductase inhibitors (statins): results from the National Health and Nutrition Examination Survey 2005-2008.Eye (London, England) · 2014Article
- Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study.PloS one · 2014Article
- Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration.Cell metabolism · 2013Article
- Protective inflammasome activation in AMD.Nature medicine · 2012Article
- The oil spill in ageing Bruch membrane.The British journal of ophthalmology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAge-related macular degeneration (AMD) is the leading cause of blindness in western societies. Statins comprise a class of pharmacological agents that reduce plasma cholesterol levels, and have been shown to prevent progression of atherosclerosis and reduce cardiovascular mortality. The relationship between these medications and AMD has been evaluated in several recent studies. Herein, we examine the current evidence for an association between statin use and risk of AMD.
methodsLiterature database search (Medline, Scopus, and Science Citation Index Expanded) for articles published up to March 2010, using particular search terms.
resultsFrom the current evidence available, it is not safe to conclude upon the assumption of a protective effect of statins against age-related maculopathy and AMD.
conclusionThere is a need for large scale prospective studies with a long follow-up period and accurate assessment of AMD to further explore this matter.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.