ArticleCell cycle (Georgetown, Tex.)2010
Cyclin T1 overexpression induces malignant transformation and tumor growth.
Article in Cell cycle (Georgetown, Tex.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Network Pharmacology-Based Identification of Potential Targets and Mechanisms of Isoginkgetin in Gastric Cancer.BioMed research international · 2026Article
- Deciphering the prognostic and therapeutic significance of BAG1 and BAG2 for predicting distinct survival outcome and effects on liposarcoma.Scientific reports · 2024Article
- A pan-cancer analysis for the oncogenic role of cyclin-dependent kinase inhibitor 1B in human cancers.Discover oncology · 2023Article
- Flavopiridol Mitigates the Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Targeting Cyclin-Dependent Kinase 9.Cardiovascular drugs and therapy · 2023Article
- P-TEFb as A Promising Therapeutic Target.Molecules (Basel, Switzerland) · 2020Review
- Regulation of cyclin T1 during HIV replication and latency establishment in human memory CD4 T cells.Virology journal · 2019Article
- Condition-adaptive fused graphical lasso (CFGL): An adaptive procedure for inferring condition-specific gene co-expression network.PLoS computational biology · 2018Article
- miR-206 inhibits the growth of hepatocellular carcinoma cells via targeting CDK9.Cancer medicine · 2017Article
- Gene Regulatory Network Analysis for Triple-Negative Breast Neoplasms by Using Gene Expression Data.Journal of breast cancer · 2017Article
- Positive cyclin T expression as a favorable prognostic factor in treating gastric gastrointestinal stromal tumors.Molecular and clinical oncology · 2016Article
- RNA polymerase II pausing as a context-dependent reader of the genome.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2016Review
- Increased cyclin T1 expression as a favorable prognostic factor in treating gastric adenocarcinoma.Oncology letters · 2015Article
- 7SK small nuclear RNA inhibits cancer cell proliferation through apoptosis induction.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Prostate tumor growth is impaired by CtBP1 depletion in high-fat diet-fed mice.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop.Nucleic acids research · 2013Article
- The novel quantitative trait locus GL3.1 controls rice grain size and yield by regulating Cyclin-T1;3.Cell research · 2012Article
- Cyclins and cell cycle control in cancer and disease.Genes & cancer · 2012Article
- LARP7 is a potential tumor suppressor gene in gastric cancer.Laboratory investigation; a journal of technical methods and pathology · 2012Article
- MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma.Carcinogenesis · 2012Article
- MicroRNA-34a modulates c-Myc transcriptional complexes to suppress malignancy in human prostate cancer cells.PloS one · 2012Article
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5 authors at 2 institutions in 2 countries.
Funding
Abstract
Human PTE Fb is a protein kinase composed by CDK9 and Cyclin T that controls the elongation phase of RNA Pol II. This complex also affects the activation and differentiation program of lymphoid cells. In this study we found that several head and neck tumor cell lines overexpress PTE Fb. We also established that Cyclin T1 is able to induce transformation in vitro, as we determined by foci and colony formation assays. Nu/nu mice s.c. injected with stable transfected Cyclin T1 cells (NIH 3T3 Cyclin T1) developed tumors faster than animals injected with control cells (NIH 3T3 beta-gal). In vitro, NIH 3T3 Cyclin T1 cells show increased proliferation and CDK4-Rb phosphorylation. Even more, silencing E2F1 expression (shRNA E2F1) in NIH 3T3 cells resulted in a dramatic inhibition of Cyclin T1-induced foci. All these data demonstrate for the first time the Cyclin T1 oncogenic function and suggest a role for this protein in controlling cell cycle probably via Rb/E2F1 pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.