Evidence map›Paper›PMID 20714213›Full record

ArticleStereotactic and functional neurosurgery2010

Differential response of dystonia and parkinsonism following globus pallidus internus deep brain stimulation in X-linked dystonia-parkinsonism (Lubag).

Genko Oyama, Hubert H Fernandez, Kelly D Foote, Pam Zeilman, Nelson Hwynn, Charles E Jacobson, Irene A Malaty, Ramon L Rodriguez, Michael S Okun

Open access · greenAbstract readCase Reports
In one paragraph

Article in Stereotactic and functional neurosurgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Progressive Decline in Voice and Voice-Related Quality of Life in X-Linked Dystonia Parkinsonism.Journal of voice : official journal of the Voice Foundation · 2023
    Article
  6. Review
  7. X-Linked Dystonia-Parkinsonism: recent advances.Current opinion in neurology · 2019
    Review
  8. Review
  9. Article
  10. Medical treatment of dystonia.Journal of clinical movement disorders · 2016
    Review
  11. Article
  12. Treatment of generalized dystonia.Current treatment options in neurology · 2011
    Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Genko OyamaDepartment of Neurology, University of Florida College of Medicine/Shands Hospital, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA.
Hubert H Fernandez
Kelly D Foote
Pam Zeilman
Nelson Hwynn
Charles E Jacobson
Irene A Malaty
Ramon L Rodriguez
Michael S Okun
Neurology, Inc · USUF Health Shands Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundX-linked dystonia-parkinsonism (XDP; DYT3; Lubag) is an adult-onset hereditary progressive dystonia/parkinsonism which is typically minimally responsive to pharmacological treatment. CASE REPORT: We report a 63- year-old man with a diagnosis of XDP who underwent bilateral globus pallidus internus deep brain stimulator (GPi-DBS) placement. His course initially began with right hand tremor and dystonia at age 57 and progressed to also include bradykinesia and rigidity. The patient tolerated the procedure without significant complications. GPi-DBS improved his right hand dystonia, but did not significantly improve his parkinsonism.

conclusionDBS may be a therapeutic option for select cases of XDP, but its specific indications must be carefully discussed, as the available cases have had mixed responses. Whether other targets may be more effective is not known.

Indexed as

Deep Brain StimulationDystoniaGenetic Diseases, X-LinkedGlobus PallidusHumansMaleMiddle AgedParkinsonian DisordersTreatment Outcome

Identifiers

PMID20714213
PMCPMC2969112
OpenAlexW2000333195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.