ReviewAnnals of internal medicine2010
Narrative review: ventilator-induced respiratory muscle weakness.
Review in Annals of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acceptable Range of Inspiratory Effort During Mechanical Ventilation
Impact of the Display of Inspiratory Muscle Pressure Curves Estimated by Artificial Intelligence on the Ability of Health Care Professionals to Correctly Identify Patient-ventilator Asynchronies - Pmus Study
Who cites it
34 citing papers in PubMed, 109 citations in OpenAlex.
- Functional Magnetic Neuromuscular Stimulation vs. Routine Physiotherapy in the Critically Ill for Prevention of ICU Acquired Muscle Loss: A Randomised Controlled Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Acute intermittent hypoxia and respiratory muscle recruitment in people with amyotrophic lateral sclerosis: A preliminary study.Experimental neurology · 2022Trial
- Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness.Intensive care medicine · 2014Trial
- The effects of inspiratory muscle training on biomarkers of muscle damage in recovered COVID-19 patients after weaning from mechanical ventilation.Chronic respiratory diseaseTrial
- Article
- Respiratory pyramid interface (RPI): a conceptual three-dimensional pyramid model for visualization of lung mechanics during mechanical ventilation.Frontiers in physiology · 2026Article
- Association between respiratory-related cortical activation and weaning from mechanical ventilation: a physiological study.Critical care (London, England) · 2025Article
- Effects of therapeutic interventions on long COVID: a meta-analysis of randomized controlled trials.EClinicalMedicine · 2025Article
- Long term diaphragmatic electrical stimulation: a case report of three cases illustrating the positive aspects and pitfalls in high spinal injury.AME case reports · 2025Article
- Review
- Article
- Neural Network-Enabled Identification of Weak Inspiratory Efforts during Pressure Support Ventilation Using Ventilator Waveforms.Journal of personalized medicine · 2023Article
- Short-term phrenic nerve stimulation; no longer a therapy in search of a disease.Journal of thoracic disease · 2022Article
- [Recommendations for outpatient respiratory rehabilitation of long COVID patients].Anales del sistema sanitario de Navarra · 2022Review
- Nosocomial COVID-19 infection mortality following surgery for severe progressive cervical myelopathy: a case report.Spinal cord series and cases · 2021Article
- Nutritional, Gastrointestinal and Endo-Metabolic Challenges in the Management of Children with Spinal Muscular Atrophy Type 1.Nutrients · 2021Review
- Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections.Med (New York, N.Y.) · 2020Review
- Expiratory muscle dysfunction in critically ill patients: towards improved understanding.Intensive care medicine · 2019Review
- Article
- Assessing breathing effort in mechanical ventilation: physiology and clinical implications.Annals of translational medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Clinicians have long been aware that substantial lung injury results when mechanical ventilation imposes too much stress on the pulmonary parenchyma. Evidence is accruing that substantial injury may also result when the ventilator imposes too little stress on the respiratory muscles. Through adjustment of ventilator settings and administration of pharmacotherapy, the respiratory muscles may be rendered almost (or completely) inactive. Research in animals has shown that diaphragmatic inactivity produces severe injury and atrophy of muscle fibers. Human data have recently revealed that 18 to 69 hours of complete diaphragmatic inactivity associated with mechanical ventilation decreased the cross-sectional areas of diaphragmatic fibers by half or more. The atrophic injury seems to result from increased oxidative stress leading to activation of protein-degradation pathways. Scientific understanding of ventilator-induced respiratory muscle injury has not reached the stage where meaningful controlled trials can be done, and thus, it is not possible to give concrete recommendations for patient management. In the meantime, clinicians are advised to select ventilator settings that avoid both excessive patient effort and excessive respiratory muscle rest. The contour of the airway pressure waveform on a ventilator screen provides the most practical indication of patient effort, and clinicians are advised to pay close attention to the waveform as they titrate ventilator settings. Research on ventilator-induced respiratory muscle injury is in its infancy and portends to be an exciting area to follow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.