ArticleInfection and immunity2010
RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Comparative analyses of the Serratia marcescens complex reveal variations in their pathogenicity against a fruit pest.Pest management science · 2026Article
- Genome-Guided Dissection of ser and shlB Uncovers Multifactorial Virulence Mechanisms of Serratia marcescens PXG6 in Plutella xylostella.Environmental microbiology · 2026Article
- Whole-genome characterization and analysis of Pantoea agglomerans R6: a genomic insight into its pathogenicity and resistance as a potential opportunistic plant pathogen.BMC genomics · 2026Article
- Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026Review
- Biosurfactants as next-generation antimicrobials: mechanistic insights and applications in antibiofilm strategies for combatting antimicrobial resistance.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- PrtA-mediated flagellar turnover is essential for robust biofilm development inApplied and environmental microbiology · 2025Article
- Debridement, Antibiotics, and Implant Retention for a Rare Serratia marcescens Infection after Total Knee Arthroplasty: A Case Report.Journal of orthopaedic case reports · 2024Article
- RecurrentTranslational pediatrics · 2024Article
- Article
- Clonal dissemination of highly virulentOne health (Amsterdam, Netherlands) · 2023Article
- Prevalence and Characterization ofInfection and drug resistance · 2023Article
- IgaA Protein, GumB, Has a Global Impact on the Transcriptome and Surface Proteome of Serratia marcescens.Infection and immunity · 2022Article
- The Rcs Stress Response System Regulator GumB Modulates Serratia marcescens-Induced Inflammation and Bacterial Proliferation in a Rabbit Keratitis Model and CytotoxicityInfection and immunity · 2021Article
- Xylitol Inhibits Growth and Blocks Virulence inMicroorganisms · 2021Article
- Differential susceptibility of airway and ocular surface cell lines to FlhDC-mediated virulence factors PhlA and ShlA fromJournal of medical microbiology · 2021Article
- Infection Due to Serratia sp. in Chronic Granulomatous Disease-Is the Incidence Low in Tropical Countries?Journal of clinical immunology · 2021Article
- Transcriptomic Analysis Reveals Competitive Growth Advantage of Non-pigmentedFrontiers in microbiology · 2021Article
- Article
- Characterization of KPC-ProducingFrontiers in microbiology · 2020Article
- Sulfur Assimilation Alters Flagellar Function and Modulates the Gene Expression Landscape of Serratia marcescens.mSystems · 2019Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serratia marcescens has long been recognized as an important opportunistic pathogen, but the underlying pathogenesis mechanism is not completely clear. Here, we report a key pathogenesis pathway in S. marcescens comprising the RssAB two-component system and its downstream elements, FlhDC and the dominant virulence factor hemolysin ShlBA. Expression of shlBA is under the positive control of FlhDC, which is repressed by RssAB signaling. At 37°C, functional RssAB inhibits swarming, represses hemolysin production, and promotes S. marcescens biofilm formation. In comparison, when rssBA is deleted, S. marcescens displays aberrant multicellularity favoring motile swarming with unbridled hemolysin production. Cellular and animal infection models further demonstrate that loss of rssBA transforms this opportunistic pathogen into hypervirulent phenotypes, leading to extensive inflammatory responses coupled with destructive and systemic infection. Hemolysin production is essential in this context. Collectively, a major virulence regulatory pathway is identified in S. marcescens.
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