ArticleGenes & development2010
The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons.
Article in Genes & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- A JNK-interacting protein 1 acts across the midline to mediate synaptic localization of the SARM1 calcium-signaling scaffold protein for asymmetric neuronal fate choice.bioRxiv : the preprint server for biology · 2026Article
- A lateralized sensory signaling pathway mediates context-dependent olfactory plasticity inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Fusogen-mediated neuron-neuron fusion disrupts neural circuit connectivity and alters animal behavior.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Combining single-cell RNA-sequencing with a molecular atlas unveils new markers for Caenorhabditis elegans neuron classes.Nucleic acids research · 2020Article
- Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans.Nature communications · 2020Article
- A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of aProceedings of the National Academy of Sciences of the United States of America · 2019Article
- A lineage-resolved molecular atlas ofScience (New York, N.Y.) · 2019Article
- Identification of Odor Blend Used by Caenorhabditis elegans for Pathogen Recognition.Chemical senses · 2018Article
- Asymmetric development of the nervous system.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Review
- Mechanisms controlling diversification of olfactory sensory neuron classes.Cellular and molecular life sciences : CMLS · 2017Review
- Stochastic left-right neuronal asymmetry in Caenorhabditis elegans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors.PLoS genetics · 2016Article
- Article
- Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways.eLife · 2016Article
- Regulation of Neuronal Oxygen Responses in C. elegans Is Mediated through Interactions between Globin 5 and the H-NOX Domains of Soluble Guanylate Cyclases.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification.PLoS genetics · 2016Article
- Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2.The EMBO journal · 2015Article
- Dissecting the signaling mechanisms underlying recognition and preference of food odors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Asymmetric neural development in the Caenorhabditis elegans olfactory system.Genesis (New York, N.Y. : 2000) · 2014Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Differentiated neurons balance the need to maintain a stable identity with their flexible responses to dynamic environmental inputs. Here we characterize these opposing influences on gene expression in Caenorhabditis elegans olfactory neurons. Using transcriptional reporters that are expressed differentially in two olfactory neurons, AWC(ON) and AWC(OFF), we identify mutations that affect the long-term maintenance of appropriate chemoreceptor expression. A newly identified gene from this screen, the conserved transcription factor hmbx-1, stabilizes AWC gene expression in adult animals through dosage-sensitive interactions with its transcriptional targets. The late action of hmbx-1 complements the early role of the transcriptional repressor gene nsy-7: Both repress expression of multiple AWC(OFF) genes in AWC(ON) neurons, but they act at different developmental stages. Environmental signals are superimposed onto this stable cell identity through at least two different transcriptional pathways that regulate individual chemoreceptor genes: a cGMP pathway regulated by sensory activity, and a daf-7 (TGF-beta)/daf-3 (SMAD repressor) pathway regulated by specific components of the density-dependent C. elegans dauer pheromone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.