ReviewClinical biochemistry2010
Tracer-based metabolomics: concepts and practices.
Review in Clinical biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Isotopic Tracer for Absolute Quantification of Metabolites of the Pentose Phosphate Pathway in Bacteria.Metabolites · 2022Review
- Review
- Comparative metabolic profiling of the lipid-producing green microalgaBiotechnology for biofuels · 2017Article
- Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics.Metabolites · 2016Article
- The Warburg effect: a balance of flux analysis.Metabolomics : Official journal of the Metabolomic Society · 2015Article
- Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery.Drug discovery today · 2014Review
- Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS.Methods in molecular biology (Clifton, N.J.) · 2014Article
- A network-based approach for predicting key enzymes explaining metabolite abundance alterations in a disease phenotype.BMC systems biology · 2013Article
- Progress toward single cell metabolomics.Current opinion in biotechnology · 2013Review
- 18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases.Croatian medical journal · 2012Review
- Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells.Nature protocols · 2012Article
- Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates.Analytical and bioanalytical chemistry · 2012Article
- Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted ³¹P NMR and mass spectrometry.Physiological genomics · 2012Article
- Inhibition of glycogen phosphorylation induces changes in cellular proteome and signaling pathways in MIA pancreatic cancer cells.Pancreas · 2012Article
- In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems.BMC systems biology · 2012Article
- UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.The EMBO journal · 2011Article
- Isotopomer enrichment assay for very short chain fatty acids and its metabolic applications.Analytical biochemistry · 2011Article
- Mathematical modeling of folate metabolism.Wiley interdisciplinary reviews. Systems biology and medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Tracer-based metabolomics is a systems biology tool that combines advances in tracer methodology for physiological studies, high throughput "-omics" technologies and constraint based modeling of metabolic networks. It is different from the commonly known metabolomics or metabonomics in that it is a targeted approach based on a metabolic network model in cells. Because of its complexity, it is the least understood among the various "-omics." In this review, the development of concepts and practices of tracer-based metabolomics is traced from the early application of radioactive isotopes in metabolic studies to the recent application of stable isotopes and isotopomer analysis using mass spectrometry; and from the modeling of biochemical reactions using flux analysis to the recent theoretical formulation of the constraint based modeling. How these newer experimental methods and concepts of constraint-based modeling approaches can be applied to metabolic studies is illustrated by examples of studies in determining metabolic responses of cells to pharmacological agents and nutrient environment changes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.