ArticleBrain research2010
Olfactory discrimination varies in mice with different levels of α7-nicotinic acetylcholine receptor expression.
Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Non-Motor Symptoms in Myasthenia Gravis Patients: Evaluation of Auditory and Olfactory Functions.Noro psikiyatri arsivi · 2026Article
- Beyond the Surface: Investigating the Potential Mechanisms of Non-Motor Symptoms in Myasthenia Gravis.European journal of neurology · 2025Review
- Cholinergic nervous system and glaucoma: From basic science to clinical applications.Progress in retinal and eye research · 2019Review
- A dominant role for the beta 4 nicotinic receptor subunit in nicotinic modulation of glomerular microcircuits in the mouse olfactory bulb.Journal of neurophysiology · 2018Article
- Generation of mice lacking DUF1220 protein domains: effects on fecundity and hyperactivity.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Editorial: Brain cholinergic mechanisms.Frontiers in synaptic neuroscience · 2015Article
- Characterizing olfactory perceptual similarity using carbon chain discrimination in Fischer 344 rats.Chemical senses · 2014Article
- Cortical odor processing in health and disease.Progress in brain research · 2014Review
- Paying attention to smell: cholinergic signaling in the olfactory bulb.Frontiers in synaptic neuroscience · 2014Review
- Nicotinic receptors modulate olfactory bulb external tufted cells via an excitation-dependent inhibitory mechanism.Journal of neurophysiology · 2013Article
- Optogenetic activation of basal forebrain cholinergic neurons modulates neuronal excitability and sensory responses in the main olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Olfaction in Parkinson's disease and related disorders.Neurobiology of disease · 2012Review
- Nicotinic receptor-mediated filtering of mitral cell responses to olfactory nerve inputs involves the α3β4 subtype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Profound olfactory dysfunction in myasthenia gravis.PloS one · 2012Article
- Galantamine improves olfactory learning in the Ts65Dn mouse model of Down syndrome.Scientific reports · 2011Article
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
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Abstract
Previous studies have shown that schizophrenics have decreased expression of α7-nicotinic acetylcholine (α7) receptors in the hippocampus and other brain regions, paranoid delusions, disorganized speech, deficits in auditory gating (i.e., inability to inhibit neuronal responses to repetitive auditory stimuli), and difficulties in odor discrimination and detection. Here we use mice with decreased α7 expression that also show a deficit in auditory gating to determine if these mice have similar deficits in olfaction. In the adult mouse olfactory bulb (OB), α7 expression localizes in the glomerular layer; however, the functional role of α7 is unknown. We show that inbred mouse strains (i.e., C3H and C57) with varying α7 expressions (e.g., α7 wild-type [α7+/+], α7 heterozygous knock-out [α7+/-] and α7 homozygous knock-out mice [α7-/-]) significantly differ in odor discrimination and detection of chemically-related odorant pairs. Using [(125)I] α-bungarotoxin (α-BGT) autoradiography, α7 expression was measured in the OB. As previously demonstrated, α-BGT binding was localized to the glomerular layer. Significantly more expression of α7 was observed in C57 α7+/+ mice compared to C3H α7+/+ mice. Furthermore, C57 α7+/+ mice were able to detect a significantly lower concentration of an odor in a mixture compared to C3H α7+/+ mice. Both C57 and C3H α7+/+ mice discriminated between chemically-related odorants sooner than α7+/- or α7-/- mice. These data suggest that α7-nicotinic-receptors contribute strongly to olfactory discrimination and detection in mice and may be one of the mechanisms producing olfactory dysfunction in schizophrenics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.