ArticleBiophysical journal2010
Ion-dependent dynamics of DNA ejections for bacteriophage lambda.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Temperature-dependent ejection evolution arising from active and passive effects in DNA viruses.Biophysical journal · 2024Article
- Coinfecting phages impede each other's entry into the cell.Current biology : CB · 2024Article
- Role of DNA-DNA sliding friction and nonequilibrium dynamics in viral genome ejection and packaging.Nucleic acids research · 2023Article
- Ion-dependent DNA configuration in bacteriophage capsids.Biophysical journal · 2021Article
- Single-particle virology.Biophysical reviews · 2020Review
- Time-resolved DNA release from an O-antigen-specificThe Journal of biological chemistry · 2019Article
- High-resolution studies of lysis-lysogeny decision-making in bacteriophage lambda.The Journal of biological chemistry · 2019Review
- Niche adaptation limits bacteriophage predation ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Identification and characterization of a novel flagellum-dependent Salmonella-infecting bacteriophage, iEPS5.Applied and environmental microbiology · 2013Article
- Structural ensemble and dynamics of toroidal-like DNA shapes in bacteriophage ϕ29 exit cavity.Biophysical journal · 2013Article
- Popping the cork: mechanisms of phage genome ejection.Nature reviews. Microbiology · 2013Review
- Polymorphism of DNA conformation inside the bacteriophage capsid.Journal of biological physics · 2013Article
- Langevin dynamics simulation of DNA ejection from a phage.Journal of biological physics · 2013Article
- Article
- A single-molecule Hershey-Chase experiment.Current biology : CB · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We studied the control parameters that govern the dynamics of in vitro DNA ejection in bacteriophage lambda. Previous work demonstrated that bacteriophage DNA is highly pressurized, and this pressure has been hypothesized to help drive DNA ejection. Ions influence this process by screening charges on DNA; however, a systematic variation of salt concentrations to explore these effects has not been undertaken. To study the nature of the forces driving DNA ejection, we performed in vitro measurements of DNA ejection in bulk and at the single-phage level. We present measurements on the dynamics of ejection and on the self-repulsion force driving ejection. We examine the role of ion concentration and identity in both measurements, and show that the charge of counterions is an important control parameter. These measurements show that the mobility of ejecting DNA is independent of ionic concentrations for a given amount of DNA in the capsid. We also present evidence that phage DNA forms loops during ejection, and confirm that this effect occurs using optical tweezers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.