ArticleBreast cancer research : BCR2010
Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations.
Article in Breast cancer research : BCR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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33 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- From Gene to Enzyme: Multidimensional Decoding of the GGT Molecular Family and Its Clinical Tumor Diagnosis.Cancer medicine · 2025Pooled it
- Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus.International journal of cancer · 2025Article
- Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes.NPJ breast cancer · 2025Review
- Immunohistochemical and molecular profiles of heterogeneous components of metaplastic breast cancer: a squamous cell carcinomatous component was distinct from a spindle cell carcinomatous component.Discover oncology · 2024Article
- Article
- Rare subtypes of triple negative breast cancer: Current understanding and future directions.NPJ breast cancer · 2023Review
- Hereditary breast cancer: syndromes, tumour pathology and molecular testing.Histopathology · 2023Review
- Apocrine lesions of the breast.Virchows Archiv : an international journal of pathology · 2022Review
- A Three-mRNA Signature Associated with Pyrimidine Metabolism for Prognosis of BRCA.BioMed research international · 2022Article
- Rare Breast Cancer Subtypes.Current oncology reports · 2021Review
- Histopathologic features of breast cancer in Li-Fraumeni syndrome.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Invasive apocrine carcinoma of the breast: clinicopathologic features and comprehensive genomic profiling of 18 pure triple-negative apocrine carcinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Correlation Between Gamma-Glutamyl Transferase Activity and Glutathione Levels in Molecular Subgroups of Breast Cancer.European journal of breast health · 2020Article
- Morphology and genomic hallmarks of breast tumours developed by ATM deleterious variant carriers.Breast cancer research : BCR · 2018Article
- Genetic basis of Cowden syndrome and its implications for clinical practice and risk management.The application of clinical genetics · 2016Review
- Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma.Oncology letters · 2015Article
- Expression of sarcosine metabolism-related proteins in estrogen receptor negative breast cancer according to the androgen receptor and HER-2 status.International journal of clinical and experimental pathology · 2015Article
- Approaches to integrating germline and tumor genomic data in cancer research.Carcinogenesis · 2014Review
- Metabolic differences in estrogen receptor-negative breast cancer based on androgen receptor status.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer.BMC cancer · 2014Article
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Authors and funding
18 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBreast carcinoma is the main malignant tumor occurring in patients with Cowden disease, a cancer-prone syndrome caused by germline mutation of the tumor suppressor gene PTEN characterized by the occurrence throughout life of hyperplastic, hamartomatous and malignant growths affecting various organs. The absence of known histological features for breast cancer arising in a PTEN-mutant background prompted us to explore them for potential new markers.
methodsWe first performed a microarray study of three tumors from patients with Cowden disease in the context of a transcriptomic study of 74 familial breast cancers. A subsequent histological and immunohistochemical study including 12 additional cases of Cowden disease breast carcinomas was performed to confirm the microarray data.
resultsUnsupervised clustering of the 74 familial tumors followed the intrinsic gene classification of breast cancer except for a group of five tumors that included the three Cowden tumors. The gene expression profile of the Cowden tumors shows considerable overlap with that of a breast cancer subgroup known as molecular apocrine breast carcinoma, which is suspected to have increased androgenic signaling and shows frequent ERBB2 amplification in sporadic tumors. The histological and immunohistochemical study showed that several cases had apocrine histological features and expressed GGT1, which is a potential new marker for apocrine breast carcinoma.
conclusionsThese data suggest that activation of the ERBB2-PI3K-AKT pathway by loss of PTEN at early stages of tumorigenesis promotes the formation of breast tumors with apocrine features.
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