ArticleAnnals of the New York Academy of Sciences2010
Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models.
Article in Annals of the New York Academy of Sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Elevated liver iron concentration is a marker of increased morbidity in patients with β thalassemia intermedia.Haematologica · 2011Trial
- Erythroid activity modulates iron regulation in pathological erythropoiesis: A cross-sectional case-control study.The Indian journal of medical research · 2025Article
- A human anti-matriptase-2 antibody limits iron overload, α-globin aggregates, and splenomegaly in β-thalassemic mice.Blood advances · 2024Article
- Intestinal calcium transport and its regulation in thalassemia: interaction between calcium and iron metabolism.The journal of physiological sciences : JPS · 2018Review
- Current Review of Iron Overload and Related Complications in Hematopoietic Stem Cell Transplantation.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2017Review
- Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from Günther disease model.Haematologica · 2017Article
- Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.Blood · 2016Article
- Iron-chelating and anti-lipid peroxidation properties of 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in long-term iron loading β-thalassemic mice.Asian Pacific journal of tropical biomedicine · 2014Article
- Identification of erythroferrone as an erythroid regulator of iron metabolism.Nature genetics · 2014Article
- An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia.Nature medicine · 2014Article
- Review
- Uptake of non-transferrin iron by erythroid cells.Anemia · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
beta-thalassemia is a disease associated with decreased beta-globin production leading to anemia, ineffective erythropoiesis, and iron overload. New mechanisms associated with modulation of erythropoiesis and iron metabolism have recently been discovered in thalassemic mice, improving our understanding of the pathophysiology of this disease. These discoveries have the potential to be translated into clinically-relevant therapeutic options to reduce ineffective erythropoiesis and iron overload. A new generation of therapies based on limiting ineffective erythropoiesis, iron absorption, and the correction of iron maldistribution could be on the way, possibly complementing and improving the current standard of patient care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.