ArticleAnalytical chemistry2010
Laser desorption postionization mass spectrometry of antibiotic-treated bacterial biofilms using tunable vacuum ultraviolet radiation.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Next Generation of Mass Spectrometry Imaging: from Micrometer to Subcellular Resolution.Chemical & biomedical imaging · 2023Review
- Two-dimensional and three-dimensional dynamic imaging of live biofilms in a microchannel by time-of-flight secondary ion mass spectrometry.Biomicrofluidics · 2015Article
- Changes in lipid distribution in E. coli strains in response to norfloxacin.Journal of mass spectrometry : JMS · 2015Article
- Emerging mass spectrometry techniques for the direct analysis of microbial colonies.Current opinion in microbiology · 2014Article
- Differentiation of microbial species and strains in coculture biofilms by multivariate analysis of laser desorption postionization mass spectra.The Analyst · 2013Article
- Laser desorption VUV postionization MS imaging of a cocultured biofilm.Analytical and bioanalytical chemistry · 2013Article
- Quantification of antibiotic in biofilm-inhibiting multilayers by 7.87 eV laser desorption postionization MS imaging.Analytical chemistry · 2012Article
- Feasibility of depth profiling of animal tissue by ultrashort pulse laser ablation.Analytical chemistry · 2012Article
- Comparing Vacuum and Extreme Ultraviolet Radiation for Postionization of Laser Desorbed Neutrals from Bacterial Biofilms and Organic Fullerenes.Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment · 2011Article
- Brominated tyrosine and polyelectrolyte multilayer analysis by laser desorption vacuum ultraviolet postionization and secondary ion mass spectrometry.Analytical chemistry · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Laser desorption postionization mass spectrometry (LDPI-MS) with 8.0-12.5 eV vacuum ultraviolet synchrotron radiation is used to single photon ionize antibiotics and extracellular neutrals that are laser desorbed both from neat and intact bacterial biofilms. Neat antibiotics are optimally detected using 10.5 eV LDPI-MS but can be ionized using 8.0 eV radiation, in agreement with prior work using 7.87 eV LDPI-MS. Tunable vacuum ultraviolet radiation also postionizes laser desorbed neutrals of antibiotics and extracellular material from within intact bacterial biofilms. Different extracellular material is observed by LDPI-MS in response to rifampicin or trimethoprim antibiotic treatment. Once again, 10.5 eV LDPI-MS displays the optimum trade-off between improved sensitivity and minimum fragmentation. Higher energy photons at 12.5 eV produce significant parent ion signal, but fragment intensity and other low mass ions are also enhanced. No matrix is added to enhance desorption, which is performed at peak power densities insufficient to directly produce ions, thus allowing observation of true VUV postionization mass spectra of antibiotic treated biofilms.
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