ArticlePediatric cardiology2010
Plasma clusterin levels in predicting the occurrence of coronary artery lesions in patients with Kawasaki disease.
Article in Pediatric cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Red blood cell distribution width predicts coronary artery lesions in Kawasaki disease: insights from a Japanese cohort.Pediatric rheumatology online journal · 2025Article
- Plasma Exosomal-Derived SERPINA1 and GNAI2 Downregulation as Potential Diagnostic Biomarkers of Kawasaki Disease with Coronary Artery Aneurysms.International journal of molecular sciences · 2025Article
- Diagnostic performances of D-dimer, prothrombin time, and red blood cell distribution width for coronary artery lesion in children with acute stage Kawasaki disease.Frontiers in pediatrics · 2023Article
- Review
- Insights Into Coronary Artery Lesions in Kawasaki Disease.Frontiers in pediatrics · 2020Review
- MiR-222-3p in Platelets Serves as a Distinguishing Marker for Early Recognition of Kawasaki Disease.Frontiers in pediatrics · 2019Article
- Biomarkers for Kawasaki Disease: Clinical Utility and the Challenges Ahead.Frontiers in pediatrics · 2019Review
- Plasma biomarkers for neuronal ceroid lipofuscinosis.The FEBS journal · 2016Article
- Descriptive epidemiology of Kawasaki disease in Japan, 2011-2012: from the results of the 22nd nationwide survey.Journal of epidemiology · 2015Article
- Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration.The Journal of biological chemistry · 2014Article
- Can Coronary Artery Involvement in Kawasaki Disease be Predicted?Diagnostics (Basel, Switzerland) · 2013Review
- Plasma clusterin concentrations may predict resistance to intravenous immunoglobulin in patients with Kawasaki disease.TheScientificWorldJournal · 2013Article
- Assessment of risk factors for Korean children with Kawasaki disease.Pediatric cardiology · 2012Article
- DC-SIGN (CD209) promoter -336 A/G (rs4804803) polymorphism associated with susceptibility of Kawasaki disease.TheScientificWorldJournal · 2012Article
- Epidemiologic features of Kawasaki disease in Japan: results of the 2009-2010 nationwide survey.Journal of epidemiology · 2012Article
- Genetic polymorphisms in Kawasaki disease.Acta pharmacologica Sinica · 2011Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kawasaki disease (KD) is the leading cause of acquired heart disease during childhood in the developed countries. Coronary artery lesions (CAL) are the major complications of KD. A unique proteomic profiling with increased or decreased fibrinogen, alpha-1-antitrypsin, clusterin, and immunoglobulin free light chains were noted in KD in our previous study. The purpose of this study was to evaluate relations between these biomarkers and CAL in KD and to establish within the markers the appropriate cut-off value with which to predict the occurrence of CAL. A total of 47 KD patients were enrolled, including 14 with CAL and 33 without CAL. Plasma samples from patients with KD before intravenous immunoglobulin administration were indicated for measurement of these biomarkers. A potential relation among CAL, clinical characteristics, and these biomarkers was investigated, and a receiver operating characteristic curve was used to identify a cut-off value of the significant marker that best predicated the occurrence of CAL. Among these biomarkers, only plasma clusterin level was associated with the occurrence of CAL. Using a cut-off value of clusterin <12.0 mg/l, the relative risk for CAL was 4.53-fold (95% confidence interval [CI] 1.060-19.347%, P = 0.014). Results from this study suggest that plasma clusterin level <12.0 mg/l in KD is significantly associated with the occurrence of CAL. Results from this study provide a potential biomarker of KD that may help predict the occurrence of CAL.
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