ArticleCancer causes & control : CCC2010
Polymorphisms in oxidative stress and inflammation pathway genes, low-dose ionizing radiation, and the risk of breast cancer among US radiologic technologists.
Article in Cancer causes & control : CCC, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Cancer Effects of Low to Moderate Doses of Ionizing Radiation in Young People with Cancer-Predisposing Conditions: A Systematic Review.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Role ofThe Journal of international medical research · 2021Pooled it
- Association of interleukin 10 rs1800896 polymorphism with susceptibility to breast cancer: a meta-analysis.The Journal of international medical research · 2020Pooled it
- Associations of common IL-4 gene polymorphisms with cancer risk: A meta-analysis.Molecular medicine reports · 2017Pooled it
- The -590C/T polymorphism in the IL-4 gene and the risk of cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Genetic Variants inFrontiers in oncology · 2021Article
- Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects ofBMC genomics · 2020Article
- Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast.Archives of toxicology · 2020Review
- Article
- Genetic polymorphisms of IL-6 promoter in cancer susceptibility and prognosis: a meta-analysis.Oncotarget · 2018Article
- Article
- Impact of COX2 genotype, ER status and body constitution on risk of early events in different treatment groups of breast cancer patients.International journal of cancer · 2014Article
- Health risks of space exploration: targeted and nontargeted oxidative injury by high-charge and high-energy particles.Antioxidants & redox signaling · 2014Review
- Lack of association between COX-2 8473T>C polymorphism and breast cancer risk: a meta-analysis.Contemporary oncology (Poznan, Poland) · 2014Article
- Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury.Cancer letters · 2012Review
- Second malignant neoplasms and cardiovascular disease following radiotherapy.Journal of the National Cancer Institute · 2012Review
Corrections and comments
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Authors and funding
12 authors at 10 institutions in 1 country.
Funding
Abstract
objectiveIonizing radiation, an established breast cancer risk factor, has been shown to induce oxidative damage and chronic inflammation. Polymorphic variation in oxidative stress and inflammatory-mediated pathway genes may modify radiation-related breast cancer risk.
methodsWe estimated breast cancer risk for 28 common variants in 16 candidate genes involved in these pathways among 859 breast cancer cases and 1,083 controls nested within the US Radiologic Technologists cohort. We estimated associations between occupational and personal diagnostic radiation exposures with breast cancer by modeling the odds ratio (OR) as a linear function in logistic regression models and assessed heterogeneity of the dose-response across genotypes.
resultsThere was suggestive evidence of an interaction between the rs5277 variant in PTGS2 and radiation-related breast cancer risk. The excess OR (EOR)/Gy from occupational radiation exposure = 5.5 (95%CI 1.2-12.5) for the GG genotype versus EOR/Gy < 0 (95%CI < 0-3.8) and EOR/Gy < 0 (95%CI < 0-14.8) for the GC and CC genotypes, respectively, (p (interaction) = 0.04). The association between radiation and breast cancer was not modified by other SNPs examined.
conclusionsThis study suggests that variation in PTGS2 may modify the breast cancer risk from occupational radiation exposure, but replication in other populations is needed to confirm this result.
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