ArticleCurrent microbiology2011
Oral administration of Clostridium butyricum for modulating gastrointestinal microflora in mice.
Article in Current microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 108 citations in OpenAlex.
- Role of probiotics in the treatment of minimal hepatic encephalopathy in patients with HBV-induced liver cirrhosis.The Journal of international medical research · 2018Trial
- Clostridium Butyricum and Bifidobacterium Supplementation Ameliorates Gut Dysbiosis and Cognitive-Anxiety Behaviors in Preterm Mice.Probiotics and antimicrobial proteins · 2026Article
- Impact of Clostridium butyricum HADIG-CB003 dietary supplementation on the gut microbiota of Kunming mice.Applied microbiology and biotechnology · 2025Article
- Supplemental illite or in combination with probiotics improves performance and intestinal health in broiler chickens challenged with Salmonella typhimurium.Journal of animal science and technology · 2025Article
- Combination of probiotics enhancing butyrogenesis in colonic microbiota model of patients with ulcerative colitis.Applied microbiology and biotechnology · 2025Article
- Review
- Article
- Probiotic Roles ofAnimals : an open access journal from MDPI · 2024Review
- Causal Associations between Gut Microbiota and Different Types of Dyslipidemia: A Two-Sample Mendelian Randomization Study.Nutrients · 2023Article
- Supplemental Clostridium butyricum modulates lipid metabolism by reshaping the gut microbiota composition and bile acid profile in IUGR suckling piglets.Journal of animal science and biotechnology · 2023Article
- Effects of dietaryFrontiers in microbiology · 2023Article
- Regulatory Effects of the ProbioticThe journal of poultry science · 2023Review
- Novel Candidate Microorganisms for Fermentation Technology: From Potential Benefits to Safety Issues.Foods (Basel, Switzerland) · 2022Review
- Enhancing egg production and quality by the supplementation of probiotic strains (Frontiers in microbiology · 2022Article
- Supplemental Clostridium butyricum MIYAIRI 588 Affects Intestinal Bacterial Composition of Finishing Pigs.Microbes and environments · 2022Article
- Dietary supplementation withAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Article
- The Recent Trend in the Use of Multistrain Probiotics in Livestock Production: An Overview.Animals : an open access journal from MDPI · 2021Review
- Overexpression of pEGF improved the gut protective function of Clostridium butyricum partly through STAT3 signal pathway.Applied microbiology and biotechnology · 2021Article
- Probiotics Improve Eating Disorders in Mandarin Fish (Microorganisms · 2021Article
- Effects ofAntibiotics (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the safety of Clostridium butyricum and to investigate the effect of C. butyricum on mice ecosystem in the intestinal tract by way of examining the population of different microorganisms isolated from caecal contents. We firstly evaluated the safety of C. butyricum using acute toxicity test and Ames test. Then forty male BALB/c mice were divided into the following four treatment groups, each consisting of ten mice: normal group, low-dose group, medium-dose group and high-dose group. Caecal contents were removed aseptically, immediately placed into an anaerobic chamber, and dissolved in sterile pre-reduced PBS. The determination of Enterococcus spp., Enterobacter spp., Lactobacillus spp., Bifidobacterium spp. and Clostridium perfringens was analyzed by the spread plate method, cell morphologies and biochemical profiles. The results showed the oral maximum tolerated dose of C. butyricum was more than 10 g/kg body weight in mice and no mutagenicity judged by negative experimental results of Ames test. And in medium- and high-dose groups, the populations of Bifidobacterium spp. and Lactobacillus spp. increased in caecum, as well as the ratios of Bifidobacterium spp. and Lactobacillus spp. to Clostridium perfringens (P < 0.01) as compared with the normal group. This research showed the intake of C. butyricum significantly improved the ecosystem of the intestinal tract in BALB/c mice by increasing the amount of probiotics and reducing the populations of unwanted bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.