Evidence map›Paper›PMID 20711694›Full record

ReviewCurrent gastroenterology reports2010

Mast cells.

Terez Shea-Donohue, Jennifer Stiltz, Aiping Zhao, Luigi Notari

Abstract readReview
In one paragraph

Review in Current gastroenterology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Dual Beneficial Effects of Topical l-Glutamine on Oral Mucositis in 5-Fluorouracil-Treated Mice.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. State of the art in research on the gut-liver and gut-brain axis in poultry.Journal of animal science and biotechnology · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Mechanisms of Immunotoxicity: Stressors and Evaluators.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Article
  13. Mast Cells as Important Regulators in Autoimmunity and Cancer Development.Frontiers in cell and developmental biology · 2021
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Terez Shea-DonohueDepartment of Medicine and Mucosal Biology Research Center, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA. tdonohue@mbrc.umaryland.edu
Jennifer Stiltz
Aiping Zhao
Luigi Notari

Funding

GI Nematodes and Gut Functional Responses to InflammationR01AI049316 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SHEA-DONOHUE, TEREZ · 2002 to 2012
$3.6M
NIAID NIH HHS R01 AI049316NIAID NIH HHS R01 AI49316
6 · The paper itself

Abstract

Mast cells have been considered for many years to participate specifically in allergic reactions through the release of cytokines, chemokines, proteases, leukotrienes, and bioactive polyamines. Emerging roles for mast cells have been identified recently, which highlight their relevance in both innate and adaptive immunity. Mast cells play a role in many different processes, including clearance of enteric pathogens, food allergies, visceral hypersensitivity, and intestinal cancer. The activation of mast cells can initiate inflammatory reactions that are life-saving in some circumstances (eg, nematode infection) but life-threatening in others (eg, allergy). In recent years, mast cells, their products, and the mechanisms by which mast cell activity can be regulated by the microenvironment are a major area of investigation. The purpose of this review article is to summarize and highlight the latest findings in mast cell biology associated with intestinal homeostasis and pathologies.

Indexed as

Adaptive ImmunityAnimalsColonic NeoplasmsCytokinesFood HypersensitivityGastrointestinal DiseasesHomeostasisHumansImmunity, InnateIntestinal MucosaMast CellsMicePeptide HydrolasesPermeabilityRatsCytokinesPeptide Hydrolases

Identifiers

PMID20711694
PMCPMC3693738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.