Evidence map›Paper›PMID 20711498›Full record

Trial reportPloS one2010

Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men.

Nicholas A Burd, Daniel W D West, Aaron W Staples, Philip J Atherton, Jeff M Baker, Daniel R Moore, Andrew M Holwerda, Gianni Parise, Michael J Rennie, Steven K Baker and 1 more

3 registry-linked trialsOpen access · goldAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 205 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 10 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03712761 completednot on this mapstarted 2018, after this paper: background citation

Supplementation of a Leucine-Enriched Dairy Protein Blend: Effects on Plasma Amino Acids in Older Adults

TypeobservationalSponsorMcMaster UniversityRan2018 to 2020Enrolled8ConditionsHealthyArmsEnriched Protein®
NCT06489886 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Nutrient and Hormonal Profile and Muscle Protein Synthesis Response to Consuming Chicken Grown Using Different Farming Practices

TypeinterventionalSponsorUniversity of California, DavisRan2024 to 2026Enrolled19ConditionsEffect of FoodArmsConventional Chicken, Regenerative Chicken
NCT07205133 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Whole Body Vibration Therapy and Usual Care Compared to Usual Care in Improving Muscle Mass, Strength and Function in Older Adults

TypeinterventionalSponsorChangi General HospitalRan2026 to 2027Enrolled40ConditionsAging, Frailty, Sarcopenia, Muscle StrengthArmsWhole Body Vibration Training, Otago Exercise
3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 10 syntheses or guidelines pooled it, 515 citations in OpenAlex.

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  9. Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods.International journal of environmental research and public health · 2019
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  15. Effects of Different Isometric Training Programs on Muscle Size and Function in the Elbow Flexors.International journal of environmental research and public health · 2023
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145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Nicholas A BurdExercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Daniel W D West
Aaron W Staples
Philip J Atherton
Jeff M Baker
Daniel R Moore
Andrew M Holwerda
Gianni Parise
Michael J Rennie
Steven K Baker
Stuart M Phillips
McMaster University · CAUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to determine the effect of resistance exercise intensity (%1 repetition maximum-1RM) and volume on muscle protein synthesis, anabolic signaling, and myogenic gene expression. METHODOLOGY/PRINCIPAL

findingsFifteen men (21+/-1 years; BMI=24.1+/-0.8 kg/m2) performed 4 sets of unilateral leg extension exercise at different exercise loads and/or volumes: 90% of repetition maximum (1RM) until volitional failure (90FAIL), 30% 1RM work-matched to 90%FAIL (30WM), or 30% 1RM performed until volitional failure (30FAIL). Infusion of [ring-13C6] phenylalanine with biopsies was used to measure rates of mixed (MIX), myofibrillar (MYO), and sarcoplasmic (SARC) protein synthesis at rest, and 4 h and 24 h after exercise. Exercise at 30WM induced a significant increase above rest in MIX (121%) and MYO (87%) protein synthesis at 4 h post-exercise and but at 24 h in the MIX only. The increase in the rate of protein synthesis in MIX and MYO at 4 h post-exercise with 90FAIL and 30FAIL was greater than 30WM, with no difference between these conditions; however, MYO remained elevated (199%) above rest at 24 h only in 30FAIL. There was a significant increase in AktSer473 at 24h in all conditions (P=0.023) and mTORSer2448 phosphorylation at 4 h post-exercise (P=0.025). Phosporylation of Erk1/2Tyr202/204, p70S6KThr389, and 4E-BP1Thr37/46 increased significantly (P<0.05) only in the 30FAIL condition at 4 h post-exercise, whereas, 4E-BP1Thr37/46 phosphorylation was greater 24 h after exercise than at rest in both 90FAIL (237%) and 30FAIL (312%) conditions. Pax7 mRNA expression increased at 24 h post-exercise (P=0.02) regardless of condition. The mRNA expression of MyoD and myogenin were consistently elevated in the 30FAIL condition. CONCLUSIONS/SIGNIFICANCE: These results suggest that low-load high volume resistance exercise is more effective in inducing acute muscle anabolism than high-load low volume or work matched resistance exercise modes.

Indexed as

Resistance TrainingExerciseGene Expression RegulationHumansIntracellular SpaceMaleMuscle Fibers, SkeletalMuscle ProteinsMyogenic Regulatory FactorsPAX7 Transcription FactorPhenylalanineRNA, MessengerSignal TransductionWeight-BearingYoung AdultMuscle ProteinsMyogenic Regulatory FactorsPAX7 protein, humanPAX7 Transcription FactorPhenylalanineRNA, Messenger

Identifiers

PMID20711498
PMCPMC2918506
OpenAlexW2160436389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.