SynthesisPloS one2010
Dietary protein and blood pressure: a systematic review.
Synthesis in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 8 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Impact of Quantity and Type of Dietary Protein on Cardiovascular Disease Risk Factors Using Standard and Network Meta-analyses of Randomized Controlled Trials.Nutrition reviews · 2025Pooled it
- Dietary protein and blood pressure: an umbrella review of systematic reviews and evaluation of the evidence.European journal of nutrition · 2024Pooled it
- The effect of healthy Nordic diet on cardio-metabolic markers: a systematic review and meta-analysis of randomized controlled clinical trials.European journal of nutrition · 2019Pooled it
- Effects of milk proteins on blood pressure: a meta-analysis of randomized control trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Pooled it
- Dietary interventions and blood pressure in Latin America - systematic review and meta-analysis.Arquivos brasileiros de cardiologia · 2014Pooled it
- Effect of dietary pulses on blood pressure: a systematic review and meta-analysis of controlled feeding trials.American journal of hypertension · 2014Pooled it
- Intake of total protein, plant protein and animal protein in relation to blood pressure: a meta-analysis of observational and intervention studies.Journal of human hypertension · 2013Pooled it
- Effects of higher- versus lower-protein diets on health outcomes: a systematic review and meta-analysis.European journal of clinical nutrition · 2012Pooled it
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- Effect of high compared with low dairy intake on blood pressure in overweight middle-aged adults: results of a randomized crossover intervention study.The American journal of clinical nutrition · 2019Trial
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- Effect of increased protein intake on renal acid load and renal hemodynamic responses.Physiological reports · 2016Trial
- A Nested Case-Control Study of Association between Metabolome and Hypertension Risk.BioMed research international · 2016Trial
- Effect of a high-protein diet on maintenance of blood pressure levels achieved after initial weight loss: the DiOGenes randomized study.Journal of human hypertension · 2015Trial
- Effects of an isocaloric healthy Nordic diet on ambulatory blood pressure in metabolic syndrome: a randomized SYSDIET sub-study.European journal of clinical nutrition · 2014Trial
- Effect of dietary protein supplementation on blood pressure: a randomized, controlled trial.Circulation · 2011Trial
- Impact of carbohydrate quality on the association between low-carbohydrate diet scores and longitudinal changes of cardiometabolic risk factors.Nutrition journal · 2025Article
- Nutritional Composition of Four Edible Grasshopper Species Frequently Consumed in Madagascar: Insights for Nutritional Contribution and Alternative Insect Farming.Foods (Basel, Switzerland) · 2025Article
- The inverse associations of glycine and histidine in diet with hyperlipidemia and hypertension.Nutrition journal · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElevated blood pressure (BP), which is a major risk factor for cardiovascular disease, is highly prevalent worldwide. Recently, interest has grown in the role of dietary protein in human BP. We performed a systematic review of all published scientific literature on dietary protein, including protein from various sources, in relation to human BP. METHODOLOGY/PRINCIPAL
findingsWe performed a MEDLINE search and a manual search to identify English language studies on the association between protein and blood pressure, published before June 2010. A total of 46 papers met the inclusion criteria. Most observational studies showed no association or an inverse association between total dietary protein and BP or incident hypertension. Results of biomarker studies and randomized controlled trials indicated a beneficial effect of protein on BP. This beneficial effect may be mainly driven by plant protein, according to results in observational studies. Data on protein from specific sources (e.g. from fish, dairy, grain, soy, and nut) were scarce. There was some evidence that BP in people with elevated BP and/or older age could be more sensitive to dietary protein. CONCLUSIONS/SIGNIFICANCE: In conclusion, evidence suggests a small beneficial effect of protein on BP, especially for plant protein. A blood pressure lowering effect of protein may have important public health implications. However, this warrants further investigation in randomized controlled trials. Furthermore, more data are needed on protein from specific sources in relation to BP, and on the protein-BP relation in population subgroups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.