ArticlePLoS genetics2010
Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during Drosophila meiosis.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 72 citations in OpenAlex.
- Tuning Meiotic Checkpoints: Evolutionary Costs and Mechanistic Trade-Offs.Annual review of genetics · 2026Review
- Meiotic pairing through barcode-like satellite DNA repeats.Nature communications · 2026Article
- The synaptonemal complex component corolla regulates meiotic crossover formation in Drosophila melanogaster.Chromosoma · 2025Article
- TRIP13 fosters both transcriptional silencing and DSB repair during meiosis.bioRxiv : the preprint server for biology · 2025Article
- Distinct cellular and reproductive consequences of meiotic chromosome synapsis defects in syce2 and sycp1 mutant zebrafish.PLoS genetics · 2025Article
- The Drosophila mauritiana synaptonemal complex protein C(3)G repatterns the recombination landscape of Drosophila melanogaster.PLoS genetics · 2025Article
- ASYNAPSIS3 has diverse dosage-dependent effects on meiotic crossover formation in Brassica napus.The Plant cell · 2024Article
- Analysis of meiotic recombination in Drosophila simulans shows no evidence of an interchromosomal effect.Genetics · 2024Article
- Article
- Structural Variants and Speciation: Multiple Processes at Play.Cold Spring Harbor perspectives in biology · 2024Review
- Genetic background effects on meiotic recombination.microPublication biology · 2024Article
- TRIP 13-dependent pathways promote the development of gastric cancer.Functional & integrative genomics · 2023Article
- Heterozygous inversion breakpoints suppress meiotic crossovers by altering recombination repair outcomes.PLoS genetics · 2023Article
- PCH-2 and meiotic HORMADs: A module for evolutionary innovation in meiosis?Current topics in developmental biology · 2023Review
- A Brief History ofGenes · 2022Review
- Does the Pachytene Checkpoint, a Feature of Meiosis, Filter Out Mistakes in Double-Strand DNA Break Repair and as a side-Effect Strongly Promote Adaptive Speciation?Integrative organismal biology (Oxford, England) · 2022Article
- Getting there: understanding the chromosomal recruitment of the AAA+ ATPase Pch2/TRIP13 during meiosis.Current genetics · 2021Review
- Mechanism and Control of Meiotic DNA Double-Strand Break Formation inFrontiers in cell and developmental biology · 2021Review
- Chromosome-autonomous feedback down-regulates meiotic DNA break competence upon synaptonemal complex formation.Genes & development · 2020Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crossovers mediate the accurate segregation of homologous chromosomes during meiosis. The widely conserved pch2 gene of Drosophila melanogaster is required for a pachytene checkpoint that delays prophase progression when genes necessary for DSB repair and crossover formation are defective. However, the underlying process that the pachytene checkpoint is monitoring remains unclear. Here we have investigated the relationship between chromosome structure and the pachytene checkpoint and show that disruptions in chromosome axis formation, caused by mutations in axis components or chromosome rearrangements, trigger a pch2-dependent delay. Accordingly, the global increase in crossovers caused by chromosome rearrangements, known as the "interchromosomal effect of crossing over," is also dependent on pch2. Checkpoint-mediated effects require the histone deacetylase Sir2, revealing a conserved functional connection between PCH2 and Sir2 in monitoring meiotic events from Saccharomyces cerevisiae to a metazoan. These findings suggest a model in which the pachytene checkpoint monitors the structure of chromosome axes and may function to promote an optimal number of crossovers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.