ArticlePLoS computational biology2010
A model for a correlated random walk based on the ordered extension of pseudopodia.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Mechanical polarity links adhesion-regulated protrusions to directional stability in glioblastoma cell migration.PLoS computational biology · 2026Article
- Persistent pseudopod splitting is an effective chemotaxis strategy in shallow gradients.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Two Complementary Signaling Pathways Depict Eukaryotic Chemotaxis: A Mechanochemical Coupling Model.Frontiers in cell and developmental biology · 2021Article
- Short- and long-term memory of moving amoeboid cells.PloS one · 2021Article
- Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration.Cell systems · 2020Article
- Article
- Screening by changes in stereotypical behavior during cell motility.Scientific reports · 2019Article
- Discrete Modeling of Amoeboid Locomotion and Chemotaxis in Dictyostelium discoideum by Tracking Pseudopodium Growth Direction.Scientific reports · 2017Article
- Determining whether observed eukaryotic cell migration indicates chemotactic responsiveness or random chemokinetic motion.Journal of theoretical biology · 2017Article
- Neural differentiation of mesenchymal stem cells influences their chemotactic responses to stromal cell-derived factor-1α.Cellular and molecular neurobiology · 2014Article
- Oscillatory behavior of neutrophils under opposing chemoattractant gradients supports a winner-take-all mechanism.PloS one · 2014Article
- Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells.PLoS computational biology · 2013Article
- P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.Immunology and cell biology · 2013Article
- Repelled from the wound, or randomly dispersed? Reverse migration behaviour of neutrophils characterized by dynamic modelling.Journal of the Royal Society, Interface · 2012Article
- Calibrating spatio-temporal models of leukocyte dynamics against in vivo live-imaging data using approximate Bayesian computation.Integrative biology : quantitative biosciences from nano to macro · 2012Article
- Article
- Nhe1 is essential for potassium but not calcium facilitation of cell motility and the monovalent cation requirement for chemotactic orientation in Dictyostelium discoideum.Eukaryotic cell · 2011Article
- A stochastic model for chemotaxis based on the ordered extension of pseudopods.Biophysical journal · 2010Article
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1 author.
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Abstract
Cell migration in the absence of external cues is well described by a correlated random walk. Most single cells move by extending protrusions called pseudopodia. To deduce how cells walk, we have analyzed the formation of pseudopodia by Dictyostelium cells. We have observed that the formation of pseudopodia is highly ordered with two types of pseudopodia: First, de novo formation of pseudopodia at random positions on the cell body, and therefore in random directions. Second, pseudopod splitting near the tip of the current pseudopod in alternating right/left directions, leading to a persistent zig-zag trajectory. Here we analyzed the probability frequency distributions of the angles between pseudopodia and used this information to design a stochastic model for cell movement. Monte Carlo simulations show that the critical elements are the ratio of persistent splitting pseudopodia relative to random de novo pseudopodia, the Left/Right alternation, the angle between pseudopodia and the variance of this angle. Experiments confirm predictions of the model, showing reduced persistence in mutants that are defective in pseudopod splitting and in mutants with an irregular cell surface.
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