ArticleOncogene2010
The CASPR2 cell adhesion molecule functions as a tumor suppressor gene in glioma.
Article in Oncogene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 32 citations in OpenAlex.
- The Tumor-suppressive role of CNTNAP2 in glioma: Dual regulation of the NDN-ERK axis and M2 macrophage polarization.Cancer gene therapy · 2026Article
- CNTNAP2: isoform- and context-specific functions in neurological disorders and cancer.Frontiers in cellular neuroscience · 2026Review
- Identifying Key Pathogenic Mechanisms in Recurrent Glioblastoma Through Bioinformatics Analysis.Current medicinal chemistry · 2026Article
- Comparison of asprosin immunoreactivity in endometrial hyperplasia and grade-1 endometrial adenocarcinoma: A retrospective case-control study.Turkish journal of obstetrics and gynecology · 2025Article
- Oligodendroglioma: Advances in Molecular Mechanisms and Immunotherapeutic Strategies.Biomedicines · 2025Review
- Article
- Identifying the Carcinogenic Mechanism of Malignant Struma Ovarii Using Whole-Exome Sequencing and DNA Methylation Analysis.Current issues in molecular biology · 2023Article
- PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas.Scientific reports · 2022Article
- Characterization of Fatty Acid Metabolism in Lung Adenocarcinoma.Frontiers in genetics · 2022Article
- Human Endogenous Retroviruses in Glioblastoma Multiforme.Microorganisms · 2021Article
- Whole-genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes.Genome biology · 2020Article
- Article
- Structure and function of the contactin-associated protein family in myelinated axons and their relationship with nerve diseases.Neural regeneration research · 2017Review
- PGBD5 promotes site-specific oncogenic mutations in human tumors.Nature genetics · 2017Article
- A Chinese female Morvan patient with LGI1 and CASPR2 antibodies: a case report.BMC neurology · 2016Article
- PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients.Acta neuropathologica communications · 2015Article
- Tumor-specific mutations in low-frequency genes affect their functional properties.Journal of neuro-oncology · 2015Article
- Tobacco smoking differently influences cell types of the innate and adaptive immune system-indications from CpG site methylation.Clinical epigenetics · 2015Article
- Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma.BMC cancer · 2014Article
- Genome-wide approach to identify second gene targets for malignant rhabdoid tumors using high-density oligonucleotide microarrays.Cancer science · 2014Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic translocations have been implicated in cancer. In this study, we performed a screen for genetic translocations in gliomas based on exon-level expression profiles. We identified a translocation in the contactin-associated protein-like 2 (CASPR2) gene, encoding a cell adhesion molecule. CASPR2 mRNA was fused to an expressed sequence tag that likely is part of the nuclear receptor coactivator 1 gene. Despite high mRNA expression levels, no CASPR2 fusion protein was detected. In a set of 25 glioblastomas and 22 oligodendrogliomas, mutation analysis identified two additional samples with genetic alterations in the CASPR2 gene and all three identified genetic alterations are likely to reduce CASPR2 protein expression levels. Methylation of the CASPR2 gene was also observed in gliomas and glioma cell lines. CASPR2-overexpressing cells showed decreased proliferation rates, likely because of an increase in apoptosis. Moreover, high CASPR2 mRNA expression level is positively correlated with survival and is an independent prognostic factor. These results indicate that CASPR2 acts as a tumor suppressor gene in glioma.
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