ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Alport alloantibodies but not Goodpasture autoantibodies induce murine glomerulonephritis: protection by quinary crosslinks locking cryptic α3(IV) collagen autoepitopes in vivo.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- A novel mouse strain optimized for chronic human antibody administration.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Peroxidasin Is a Novel Target of Autoantibodies in Lupus Nephritis.Kidney international reports · 2019Article
- Goodpasture's autoimmune disease - A collagen IV disorder.Matrix biology : journal of the International Society for Matrix Biology · 2018Review
- Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy.Frontiers in immunology · 2018Article
- Basement membranes and autoimmune diseases.Matrix biology : journal of the International Society for Matrix Biology · 2017Review
- Atypical anti-glomerular basement membrane disease: lessons learned.Clinical kidney journal · 2016Article
- Optimizing the translational value of animal models of glomerulonephritis: insights from recent murine prototypes.American journal of physiology. Renal physiology · 2016Review
- Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen.Molecular immunology · 2016Article
- Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models.Journal of translational medicine · 2015Article
- Neonatal Fc receptor promotes immune complex-mediated glomerular disease.Journal of the American Society of Nephrology : JASN · 2014Article
- Quaternary epitopes of α345(IV) collagen initiate Alport post-transplant anti-GBM nephritis.Journal of the American Society of Nephrology : JASN · 2013Article
- Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-glomerular basement membrane autoantibodies specific for α345NC1 hexamers.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases.BMC immunology · 2012Article
- Murine membranous nephropathy: immunization with α3(IV) collagen fragment induces subepithelial immune complexes and FcγR-independent nephrotic syndrome.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Goodpasture's disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis.Current opinion in nephrology and hypertension · 2011Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The noncollagenous (NC1) domains of alpha3alpha4alpha5(IV) collagen in the glomerular basement membrane (GBM) are targets of Goodpasture autoantibodies or Alport posttransplant nephritis alloantibodies mediating rapidly progressive glomerulonephritis. Because the autoepitopes but not the alloepitopes become cryptic upon assembly of alpha3alpha4alpha5NC1 hexamers, we investigated how the accessibility of B cell epitopes in vivo influences the development of glomerulonephritis in mice passively immunized with human anti-GBM Abs. Alport alloantibodies, which bound to native murine alpha3alpha4alpha5NC1 hexamers in vitro, deposited linearly along the mouse GBM in vivo, eliciting crescentic glomerulonephritis in Fcgr2b(-/-) mice susceptible to Ab-mediated inflammation. Goodpasture autoantibodies, which bound to murine alpha3NC1 monomer and dimer subunits but not to native alpha3alpha4alpha5NC1 hexamers in vitro, neither bound to the mouse GBM in vivo nor induced experimental glomerulonephritis. This was due to quinary NC1 crosslinks, recently identified as sulfilimine bonds, which comprehensively locked the cryptic Goodpasture autoepitopes in the mouse GBM. In contrast, non-crosslinked alpha3NC1 subunits were identified as a native target of Goodpasture autoantibodies in the GBM of squirrel monkeys, a species susceptible to Goodpasture autoantibody-mediated nephritis. Thus, crypticity of B cell autoepitopes in tissues uncouples potentially pathogenic autoantibodies from autoimmune disease. Crosslinking of alpha3alpha4alpha5NC1 hexamers represents a novel mechanism averting autoantibody binding and subsequent tissue injury by posttranslational modifications of an autoantigen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.