ArticleApplied and environmental microbiology2010
Comparison of single- and multilocus genetic diversity in the protozoan parasites Cryptosporidium parvum and C. hominis.
Article in Applied and environmental microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
- Population structure and zoonotic potential of Cryptosporidium parvum in Italy inferred using a multi-locus sequence typing scheme.Parasites & vectors · 2026Article
- Risk Factors and Circulating Subtypes ofMicroorganisms · 2025Article
- Cryptosporidiosis: A global threat to human and animal health.Open veterinary journal · 2025Review
- A review of recentCurrent research in parasitology & vector-borne diseases · 2025Review
- Article
- Parapipe: a pipeline for parasite next-generation sequencing data analysis applied to Cryptosporidium.Access microbiology · 2025Article
- Review
- Genomic Heterogeneity of Cryptosporidium parvum Isolates From Children in Bangladesh: Implications for Parasite Biology and Human Infection.The Journal of infectious diseases · 2023Article
- Application of a new multi-locus variable number tandem repeat analysis (MLVA) scheme for the seasonal investigation ofCurrent research in parasitology & vector-borne diseases · 2023Article
- Validation of a multilocus genotyping scheme for subtypingFood and waterborne parasitology · 2022Article
- Article
- Population structure and geographical segregation of Cryptosporidium parvum IId subtypes in cattle in China.Parasites & vectors · 2020Article
- Direct Sequencing ofFrontiers in public health · 2019Review
- Evolutionary processes in populations of Cryptosporidium inferred from gp60 sequence data.Parasitology research · 2017Article
- Comparative genomic analysis of the IId subtype family of Cryptosporidium parvum.International journal for parasitology · 2017Article
- Towards a consensus on genotyping schemes for surveillance and outbreak investigations of Cryptosporidium, Berlin, June 2016.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2016Article
- Molecular characterization of Cryptosporidium parvum from two different Japanese prefectures, Okinawa and Hokkaido.Parasitology international · 2015Article
- Molecular testing for clinical diagnosis and epidemiological investigations of intestinal parasitic infections.Clinical microbiology reviews · 2014Review
- Cryptosporidium,Giardia, Cryptococcus, Pneumocystis genetic variability: cryptic biological species or clonal near-clades?PLoS pathogens · 2014Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The genotyping of numerous isolates of Cryptosporidium parasites has led to the definition of new species and a better understanding of the epidemiology of cryptosporidiosis. A single-locus genotyping method based on the partial sequence of a polymorphic sporozoite surface glycoprotein gene (GP60) has been favored by many for surveying Cryptosporidium parvum and C. hominis populations. Since genetically distinct Cryptosporidium parasites recombine in nature, it is unclear whether single-locus classifications can adequately represent intraspecies diversity. To address this question, we investigated whether multilocus genotypes of C. parvum and C. hominis cluster according to the GP60 genotype. C. hominis multilocus genotypes did not segregate according to this marker, indicating that for this species the GP60 sequence is not a valid surrogate for multilocus typing methods. In contrast, in C. parvum the previously described "anthroponotic" genotype was confirmed as a genetically distinct subspecies cluster characterized by a diagnostic GP60 allele. However, as in C. hominis, several C. parvum GP60 alleles did not correlate with distinct subpopulations. Given the rarity of some C. parvum GP60 alleles in our sample, the existence of additional C. parvum subgroups with unique GP60 alleles cannot be ruled out. We conclude that with the exception of genotypically distinct C. parvum subgroups, multilocus genotyping methods are needed to characterize C. parvum and C. hominis populations. Unless parasite virulence is controlled at the GP60 locus, attempts to find associations within species or subspecies between GP60 and phenotype are unlikely to be successful.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.