ArticleThe Journal of thoracic and cardiovascular surgery2011
Role of biofilm in Staphylococcus aureus and Staphylococcus epidermidis ventricular assist device driveline infections.
Article in The Journal of thoracic and cardiovascular surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 82 citations in OpenAlex.
- Prospective, multicenter study of ventricular assist device infections.Circulation · 2013Trial
- Driveline Relocation and Vacuum-Assisted Closure for Ventricular Assist Device Driveline Infections.Journal of cardiovascular development and disease · 2025Article
- Clinical outcomes of modified left ventricular assist device driveline management.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Targeting Chronic Biofilm Infections With Patient-derived Phages: An In Vitro and Ex Vivo Proof-of-concept Study in Patients With Left Ventricular Assist Devices.Open forum infectious diseases · 2025Article
- Infections in Patients with Mechanical Circulatory Support.Infectious disease clinics of North America · 2024Review
- In-vitro external fixation pin-site model proof of concept: A novel approach to studying wound healing in transcutaneous implants.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2024Article
- Anti-infective characteristics of a new Carbothane ventricular assist device driveline.Biofilm · 2023Article
- Abnormal magnetic resonance imaging signal in the burr hole and the identification of the intracranial infection of a deep brain stimulation device: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Nontuberculous Mycobacterial Infections Associated With Left Ventricular Assist Devices in 3 Patients.Texas Heart Institute journal · 2022Review
- Systems of conductive skin for power transfer in clinical applications.European biophysics journal : EBJ · 2022Review
- HFA of the ESC position paper on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider Part 3: at the hospital and discharge.ESC heart failure · 2021Article
- The Vaginal Microbiota, Bacterial Biofilms and Polymeric Drug-Releasing Vaginal Rings.Pharmaceutics · 2021Review
- Left ventricular assist device driveline infections in three contemporary devices.Artificial organs · 2021Article
- Ventricular Assist Device-Specific Infections.Journal of clinical medicine · 2021Review
- In Full Flow: Left Ventricular Assist Device Infections in the Modern Era.Open forum infectious diseases · 2020Review
- AnFrontiers in microbiology · 2020Article
- Re-Potentiation of β-Lactam Antibiotic by Synergistic Combination with Biogenic Copper Oxide Nanocubes against Biofilm Forming Multidrug-Resistant Bacteria.Molecules (Basel, Switzerland) · 2019Article
- MgrA Negatively Regulates Biofilm Formation and Detachment by Repressing the Expression ofApplied and environmental microbiology · 2018Article
- Surface micropattern reduces colonization and medical device-associated infections.Journal of medical microbiology · 2017Article
- Driveline Infection in Ventricular Assist Devices and Its Implication in the Present Era of Destination Therapy.Open journal of cardiovascular surgery · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveInfections, especially those involving drivelines, are among the most serious complications that follow ventricular assist device implantation. Staphylococci are the most common causes of these infections. Once driveline infections are established, they can remain localized or progress as an ascending infection to cause metastatic seeding of other tissue sites. Although elaboration of biofilm appears to be critical in prosthetic device infections, its role as a facilitator of staphylococcal infection and migration along the driveline and other prosthetic devices is unclear.
methodsA murine model of driveline infection was used to investigate staphylococcal migration along the driveline. A biofilm-producing strain of Staphylococcus epidermidis and a Staphylococcus aureus strain and its intercellular adhesion gene cluster (ica)-negative (biofilm-deficient) isogenic mutant were used in these studies. Bacterial density on the driveline and the underlying tissue was measured over time. Scanning electron microscopy was used to examine the morphology of S epidermidis biofilm formation as the infection progressed.
resultsThe biofilm-deficient S aureus mutant was less effective at infecting and migrating along the driveline than the wild-type strain over time. However, the ica mutation had no effect on the ability of the strain to infect underlying tissue. S aureus exhibited more rapid migration than S epidermidis. Scanning electron microscopy revealed the deposition of host matrix on the Dacron material after implantation. This was followed by elaboration of a bacterial biofilm that correlated with more rapid migration along the driveline.
conclusionsBiofilm formation is a critical virulence determinant that facilitates the progression of drivelines infections.
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