ArticleBiochemical and biophysical research communications2010
Drosophila Sld5 is essential for normal cell cycle progression and maintenance of genomic integrity.
Article in Biochemical and biophysical research communications, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Comprehensive analysis ofTranslational andrology and urology · 2024Article
- Unwinding the Role of the CMG Helicase in Inborn Errors of Immunity.Journal of clinical immunology · 2023Article
- Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye.Developmental cell · 2023Article
- Comprehensive analysis of GINS subunits prognostic value and ceRNA network in sarcoma.Frontiers in cell and developmental biology · 2022Article
- A pan-cancer analysis of GINS complex subunit 4 to identify its potential role as a biomarker in multiple human cancers.American journal of cancer research · 2022Article
- Multiple RNA virus matrix proteins interact with SLD5 to manipulate host cell cycle.The Journal of general virology · 2021Article
- Overexpression of GINS4 Is Associated With Tumor Progression and Poor Survival in Hepatocellular Carcinoma.Frontiers in oncology · 2021Article
- GINS complex subunit 4, a prognostic biomarker and reversely mediated by Krüppel-like factor 4, promotes the growth of colorectal cancer.Cancer science · 2020Article
- Tissue-Specific Requirement for the GINS Complex During Zebrafish Development.Frontiers in cell and developmental biology · 2020Article
- Sld5 Ensures Centrosomal Resistance to Congression Forces by Preserving Centriolar Satellites.Molecular and cellular biology · 2018Article
- Archaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCM.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells.Scientific reports · 2016Article
- DNA damage enhanced by the attenuation of SLD5 delays cell cycle restoration in normal cells but not in cancer cells.PloS one · 2014Article
- Requirement of SLD5 for early embryogenesis.PloS one · 2013Article
- Drosophila Psf2 has a role in chromosome condensation.Chromosoma · 2012Article
- Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression.BMC molecular biology · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Essential for the normal functioning of a cell is the maintenance of genomic integrity. Failure in this process is often catastrophic for the organism, leading to cell death or mis-proliferation. Central to genomic integrity is the faithful replication of DNA during S phase. The GINS complex has recently come to light as a critical player in DNA replication through stabilization of MCM2-7 and Cdc45 as a member of the CMG complex which is likely responsible for the processivity of helicase activity during S phase. The GINS complex is made up of 4 members in a 1:1:1:1 ratio: Psf1, Psf2, Psf3, And Sld5. Here we present the first analysis of the function of the Sld5 subunit in a multicellular organism. We show that Drosophila Sld5 interacts with Psf1, Psf2, and Mcm10 and that mutations in Sld5 lead to M and S phase delays with chromosomes exhibiting hallmarks of genomic instability.
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