ArticleCancer epidemiology2011
Cardiorespiratory fitness and risk of prostate cancer: findings from the Aerobics Center Longitudinal Study.
Article in Cancer epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 5 citations in OpenAlex.
- A diet, physical activity, and stress reduction intervention in men with rising prostate-specific antigen after treatment for prostate cancer.Cancer epidemiology · 2012Trial
- Nonexercise estimated cardiorespiratory fitness in relation to incidence of urinary tract, bladder and kidney cancer in the HUNT study.Scientific reports · 2025Article
- Article
- Adolescent cardiorespiratory fitness and risk of cancer in late adulthood: A nationwide sibling-controlled cohort study in Sweden.PLoS medicine · 2025Article
- Unraveling the link between cardiorespiratory fitness and cancer: a state-of-the-art review.GeroScience · 2024Review
- Association between change in cardiorespiratory fitness and prostate cancer incidence and mortality in 57 652 Swedish men.British journal of sports medicine · 2024Article
- Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study.British journal of cancer · 2024Article
- Association Between Cardiorespiratory Fitness and Cancer Incidence and Cancer-Specific Mortality of Colon, Lung, and Prostate Cancer Among Swedish Men.JAMA network open · 2023Article
- Early-Life Cardiorespiratory Fitness and Long-term Risk of Prostate Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020Article
- Cardiorespiratory fitness and cancer in women: A prospective pilot study.Journal of sport and health science · 2019Article
- Main and interactive effects of physical activity, fitness and body mass in the prevention of cancer from the Copenhagen Male Study.Scientific reports · 2018Article
- Cardiorespiratory fitness and risk of site-specific cancers: a long-term prospective cohort study.Cancer medicine · 2017Article
- Relationship Between Aerobic Fitness, the Serum IGF-1 Profiles of Healthy Young Adult African American Males, and Growth of Prostate Cancer Cells.American journal of men's health · 2017Article
- Measured cardiorespiratory fitness and self-reported physical activity: associations with cancer risk and death in a long-term prospective cohort study.Cancer medicine · 2016Article
- Exercise volume and aerobic fitness in young adults: the Midwest Exercise Trial-2.SpringerPlus · 2016Article
- Midlife Cardiorespiratory Fitness, Incident Cancer, and Survival After Cancer in Men: The Cooper Center Longitudinal Study.JAMA oncology · 2015Observational
- Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men.BMC public health · 2014Article
- Creating a cadre of junior investigators to address the challenges of cancer-related health disparities: lessons learned from the community networks program.Journal of cancer education : the official journal of the American Association for Cancer Education · 2012Article
- Intake of grains and dietary fiber and prostate cancer aggressiveness by race.Prostate cancer · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association between cardiorespiratory fitness (CRF) and risk of incident prostate cancer (PrCA).
methodsParticipants were 19,042 male subjects in the Aerobics Center Longitudinal Study (ACLS), ages 20-82years, who received a baseline medical examination including a maximal treadmill exercise test between 1976 and 2003. CRF levels were defined as low (lowest 20%), moderate (middle 40%), and high (upper 40%) according to age-specific distribution of treadmill duration from the overall ACLS population. PrCA was assessed from responses to mail-back health surveys during 1982-2004. Cox proportional hazards regression models, adjusted for potential confounders, were used to compute hazard ratios (HRs), 95% confidence intervals (95% CIs), and incidence rates (per 10,000 person-years of follow-up).
resultsA total of 634 men reported a diagnosis of incident PrCA during an average of 9.3 ± 7.1 years of follow-up. Adjusted HRs (95% CIs) in men with moderate and high CRF relative to low CRF were, 1.68 (1.13-2.48) and 1.74 (1.15-2.62), respectively. The positive association between CRF and PrCA was observed only in the strata of men who were not obese, had ≥ 1 follow-up examination, or who were diagnosed ≤ 1995.
conclusionsRather than revealing a causal relationship, the unexpected positive association observed between CRF and incident PrCA is most likely due to a screening/detection bias in more fit men who also are more health-conscious. Results have important implications for understanding the health-related factors that predispose men to receive PrCA screening that may lead to over-detection of indolent disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.