ArticleNeurobiology of aging2012
Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease.
Article in Neurobiology of aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of prolonged voluntary wheel running on oxidative stress and defence mechanisms in cortex and hippocampus of healthy female rats.Experimental physiology · 2026Article
- The role of aging and brain-derived neurotrophic factor signaling in expression of base excision repair genes in the human brain.Aging cell · 2023Article
- Review
- Natural Molecules From Chinese Herbs Protecting Against Parkinson's Disease via Anti-oxidative Stress.Frontiers in aging neuroscience · 2018Article
- Near infrared light decreases synaptic vulnerability to amyloid beta oligomers.Scientific reports · 2017Article
- Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair.Frontiers in aging neuroscience · 2017Article
- The impact of base excision DNA repair in age-related neurodegenerative diseases.Mutation research · 2015Review
- The role of mitochondrial DNA mutation on neurodegenerative diseases.Experimental & molecular medicine · 2015Review
- Mitochondrial DNA deletions in Alzheimer's brains: a review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2014Review
- DNA repair mechanisms in dividing and non-dividing cells.DNA repair · 2013Review
- Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease.Antioxidants & redox signaling · 2013Review
- Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration.Neurochemistry international · 2013Review
- DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease.Alzheimer's research & therapy · 2013Review
- Neurodegeneration as an RNA disorder.Progress in neurobiology · 2012Review
- Nuclear and mitochondrial DNA repair in selected eukaryotic aging model systems.Oxidative medicine and cellular longevity · 2012Review
- Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage.Rejuvenation research · 2011Article
- DNA repair deficiency in neurodegeneration.Progress in neurobiology · 2011Review
- To live or to die: a matter of processing damaged DNA termini in neurons.EMBO molecular medicine · 2011Review
- DNA damage and base excision repair in mitochondria and their role in aging.Journal of aging research · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Brain aging is associated with synaptic decline and synaptic function is highly dependent on mitochondria. Increased levels of oxidative DNA base damage and accumulation of mitochondrial DNA (mtDNA) mutations or deletions lead to mitochondrial dysfunction, playing an important role in the aging process and the pathogenesis of several neurodegenerative diseases. Here we have investigated the repair of oxidative base damage, in synaptosomes of mouse brain during normal aging and in an AD model. During normal aging, a reduction in the base excision repair (BER) capacity was observed in the synaptosomal fraction, which was associated with a decrease in the level of BER proteins. However, we did not observe changes between the synaptosomal BER activities of presymptomatic and symptomatic AD mice harboring mutated amyolid precursor protein (APP), Tau, and presinilin-1 (PS1) (3xTgAD). Our findings suggest that the age-related reduction in BER capacity in the synaptosomal fraction might contribute to mitochondrial and synaptic dysfunction during aging. The development of AD-like pathology in the 3xTgAD mouse model was, however, not associated with deficiencies of the BER mechanisms in the synaptosomal fraction when the whole brain was analyzed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.