ReviewAgeing research reviews2010
The role of genetic variants in human longevity.
Review in Ageing research reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Association between FOXO3A gene polymorphisms and human longevity: a meta-analysis.Asian journal of andrologyPooled it
- Lifespan and Fecundity Impacts of Reduced Insulin Signalling Can Be Directed by Mito-Nuclear Epistasis in Drosophila.Aging cell · 2026Article
- Impaired ketogenesis in Leydig Cells drives testicular aging.Nature communications · 2025Article
- Gut microbiota in centenarians: A potential metabolic and aging regulator in the study of extreme longevity.Aging medicine (Milton (N.S.W)) · 2024Review
- Global Research on Centenarians: A Historical and Comprehensive Bibliometric Analysis from 1887 to 2023.Annals of geriatric medicine and research · 2024Article
- Blood biomarker profiles and exceptional longevity: comparison of centenarians and non-centenarians in a 35-year follow-up of the Swedish AMORIS cohort.GeroScience · 2024Article
- A single-cell transcriptomic landscape of primate arterial aging.Nature communications · 2020Article
- Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- What Can We Learn About Human Disease from the Nematode C. elegans?Methods in molecular biology (Clifton, N.J.) · 2018Review
- FOXO3 longevity interactome on chromosome 6.Aging cell · 2017Article
- Association study of polymorphisms in FOXO3, AKT1 and IGF-2R genes with human longevity in a Han Chinese population.Oncotarget · 2016Article
- Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)".Age (Dordrecht, Netherlands) · 2014Article
- Gender-specific DNA methylome analysis of a Han Chinese longevity population.BioMed research international · 2014Article
- MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping.Age (Dordrecht, Netherlands) · 2013Article
- Linkage and association of successful aging to the 6q25 region in large Amish kindreds.Age (Dordrecht, Netherlands) · 2013Article
- Article
- PTEN in cancer, metabolism, and aging.Trends in endocrinology and metabolism: TEM · 2013Review
- Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.Age (Dordrecht, Netherlands) · 2013Article
- FOXO3 gene variants and human aging: coding variants may not be key players.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity.Immunity & ageing : I & A · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human longevity is a complex phenotype with a strong genetic predisposition. Increasing evidence has revealed the genetic antecedents of human longevity. This article aims to review the data of various case/control association studies that examine the difference in genetic polymorphisms between long-lived people and younger subjects across different human populations. There are more than 100 candidate genes potentially involved in human longevity; this article particularly focuses on genes of the insulin/IGF-1 pathway, FOXO3A, FOXO1A, lipoprotein metabolism (e.g., APOE and PON1), and cell-cycle regulators (e.g., TP53 and P21). Since the confirmed genetic components for human longevity are few to date, further precise assessment of the genetic contributions is required. Gaining a better understanding of the contribution of genetics to human longevity may assist in the design of improved treatment methods for age-related diseases, delay the aging process, and, ultimately, prolong the human lifespan.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.