ArticleThe international journal of biochemistry & cell biology2011
Inactivation of p38 MAPK during liver regeneration.
Article in The international journal of biochemistry & cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- Network Pharmacology, Molecular Docking, Molecular Dynamics to Explore the Mechanism of Danggui Shaoyao Powder for Hepatic Encephalopathy.Current pharmaceutical design · 2025Article
- Interleukin-1β Signaling Contributes to Cell Cycle Arrest and Apoptotic Cell Death by Leptin via Modulation of AKT and p38MAPK in Hepatocytes.Biomolecules & therapeutics · 2024Article
- Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical, molecular, and computational studies.Animal models and experimental medicine · 2024Article
- Mechanism of Metabolic Response to Hepatectomy by Integrated Analysis of Gut Microbiota, Metabolomics, and Proteomics.Microbiology spectrum · 2023Article
- Identification of therapeutic targets in a murine model of severe exertional heat stroke.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- LR12 Promotes Liver Repair by Improving the Resolution of Inflammation and Liver Regeneration in Mice with Thioacetamide- (TAA-) Induced Acute Liver Failure.Mediators of inflammation · 2021Article
- Function of Mitogen-Activated Protein Kinases in Hepatic Inflammation.Journal of cellular signaling · 2021Article
- The role of stress kinases in metabolic disease.Nature reviews. Endocrinology · 2020Review
- Integrating Old and New Paradigms of G1/S Control.Molecular cell · 2020Review
- GRHL2 induces liver fibrosis and intestinal mucosal barrier dysfunction in non-alcoholic fatty liver disease via microRNA-200 and the MAPK pathway.Journal of cellular and molecular medicine · 2020Article
- Jie-Du-Hua-Yu Granules Promote Liver Regeneration in Rat Models of Acute Liver Failure: miRNA-mRNA Expression Analysis.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Hepatospecific ablation of p38α MAPK governs liver regeneration through modulation of inflammatory response to CClScientific reports · 2019Article
- p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury.Scientific reports · 2019Article
- Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability.Frontiers in pharmacology · 2018Article
- IL-1β-induced and p38The Journal of biological chemistry · 2017Article
- p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging.PloS one · 2017Article
- Caveolin-1 is essential in the differentiation of human adipose-derived stem cells into hepatocyte-like cells via an MAPK pathway-dependent mechanism.Molecular medicine reports · 2016Article
- Weaning Induced Hepatic Oxidative Stress, Apoptosis, and Aminotransferases through MAPK Signaling Pathways in Piglets.Oxidative medicine and cellular longevity · 2016Article
- Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation.World journal of gastroenterology · 2015Article
- Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents.Molecular and cellular biochemistry · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
There is increasing evidence that p38 MAPK, which is classified as a stress-activated kinase, also participates in cell cycle regulation, functioning as a suppressor of cell proliferation and tumorigenesis. We conducted a study of p38 MAPK phosphorylation during liver regeneration in mice to determine whether p38 MAPK activation or inactivation may correlate with events that lead to DNA replication after partial hepatectomy (PH), and whether p38 MAPK activation may be required for hepatocyte DNA replication in vivo and in culture. We report that active p38 (Pi-p38 MAPK) is present in normal liver, is rapidly inactivated starting 30 min after PH, and is re-activated by 12h. Although levels of Pi-MKK 3/6, the upstream kinases that activate p38 MAPK increase after PH, the expression of the dual protein phosphatase 1 is also elevated, and may be responsible for Pi-p38 MAPK dephosphorylation after PH. Inactivation and re-activation of p38 MAPK inversely correlates with the stimulation of protein synthesis and translation pathways, as indicated by activation of p70S6 kinase, increases in the phosphorylation of initiation factor elF-4E and translational repressor, 4E-BP. The activity of a p38 MAPK downstream substrate, MAPKAPK2 (MK2), did not reflect the changing levels of Pi-p38 MAPK during liver regeneration. Pi-p38 MAPK may be involved in TNF-stimulated DNA replication of murine hepatocytes in culture, but is not necessary for hepatocyte DNA replication after PH. Our results suggest that p38 MAPK inactivation plays a permissible role in DNA replication during liver regeneration and is consistent with a role for p38 MAPK in the maintenance of hepatocyte cell cycle arrest in adult liver.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.