ArticleThe Biochemical journal2010
Domain structure elucidation of human decorin glycosaminoglycans.
Article in The Biochemical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- LC-MS/MS characterization of xyloside-primed glycosaminoglycans with cytotoxic properties reveals structural diversity and novel glycan modifications.The Journal of biological chemistry · 2018Article
- Sequencing the Dermatan Sulfate Chain of Decorin.Journal of the American Chemical Society · 2017Article
- Proteoglycans and their heterogeneous glycosaminoglycans at the atomic scale.Biomacromolecules · 2015Article
- Article
- Isolation of bovine corneal keratan sulfate and its growth factor and morphogen binding.The FEBS journal · 2013Article
- Neoproteoglycans in tissue engineering.The FEBS journal · 2013Review
- Sequence analysis and domain motifs in the porcine skin decorin glycosaminoglycan chain.The Journal of biological chemistry · 2013Article
- Disaccharide analysis of glycosaminoglycans using hydrophilic interaction chromatography and mass spectrometry.Analytical chemistry · 2013Article
- Solution structure of decorin-binding protein A from Borrelia burgdorferi.Biochemistry · 2012Article
- Proteoglycan sequence.Molecular bioSystems · 2012Review
- The proteoglycan bikunin has a defined sequence.Nature chemical biology · 2011Article
- Patient-to-patient variability in autologous pericardial matrix scaffolds for cardiac repair.Journal of cardiovascular translational research · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The structure of the GAG (glycosaminoglycan) chain of recombinantly expressed decorin proteoglycan was examined using a combination of intact-chain analysis and domain compositional analysis. The GAG had a number-average molecular mass of 22 kDa as determined by PAGE. NMR spectroscopic analysis using two-dimensional correlation spectroscopy indicated that the ratio of glucuronic acid to iduronic acid in decorin peptidoglycan was 5 to 1. GAG domains terminated with a specific disaccharide obtained by enzymatic degradation of decorin GAG with highly specific endolytic and exolytic lyases were analysed by PAGE and further depolymerized with the enzymes. The disaccharide compositional profiles of the resulting domains were obtained using LC with mass spectrometric and photometric detection and compared with that of the polysaccharide. The information obtained through the disaccharide compositional profiling was combined with the NMR and PAGE data to construct a map of the decorin GAG sequence motifs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.