ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2010
Nicotine withdrawal symptoms in adolescent and adult twins.
Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- What a difference a day makes: differences in initial abstinence response during a smoking cessation attempt.Addiction (Abingdon, England) · 2017Trial
- Association between nicotine withdrawal and reward responsiveness in humans and rats.JAMA psychiatry · 2014Trial
- Smoking- and menstrual-related symptomatology during short-term smoking abstinence by menstrual phase and depressive symptoms.Addictive behaviors · 2014Trial
- Adolescent nicotine exposure affects later-life nicotine reward and withdrawal in mice.Pharmacology, biochemistry, and behavior · 2025Article
- Epigenetic and genetic profiling of comorbidity patterns among substance dependence diagnoses.Molecular psychiatry · 2025Article
- Depression and Nicotine Withdrawal Associations with Combustible and Electronic Cigarette Use.International journal of environmental research and public health · 2020Article
- A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke.Molecular psychiatry · 2017Article
- Risk factors influencing smoking behavior: a Turkish twin study.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2014Article
- Massive withdrawal symptoms and affective vulnerability are associated with variants of the CHRNA4 gene in a subgroup of smokers.PloS one · 2014Article
- Sex differences in negative affect and lapse behavior during acute tobacco abstinence: a laboratory study.Experimental and clinical psychopharmacology · 2013Article
- The association between workplace smoking bans and self-perceived, work-related stress among smoking workers.BMC public health · 2012Article
- Development of the motivational system during adolescence, and its sensitivity to disruption by nicotine.Developmental cognitive neuroscience · 2011Review
- A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families.The American journal of psychiatry · 2011Article
- Adolescent mental health as a risk factor for adolescent smoking onset.Adolescent health, medicine and therapeutics · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
We examined the variation and heritability of DSM-IV nicotine withdrawal (NW) in adult and adolescent male and female twin cigarette smokers (who reported smoking 100 or more cigarettes lifetime). Telephone diagnostic interviews were completed with 3,112 Australian adult male and female smokers (53% women; age: 24-36) and 702 Missouri adolescent male and female smokers (59% girls; age: 15-21). No gender or cohort differences emerged in rates of meeting criteria for NW (44%). Latent class analyses found that NW symptoms were best conceptualized as a severity continuum (three levels in adults and two levels in adolescents). Across all groups, increasing NW severity was associated with difficulty quitting, impairment following cessation, heavy smoking, depression, anxiety, conduct disorder and problems with alcohol use. NW was also associated with seeking smoking cessation treatment and with smoking persistence in adults. The latent class structure of NW was equally heritable across adult and adolescent smokers with additive genetic influences accounting for 49% of the variance and the remaining 51% of variance accounted for by unique environmental influences. Overall, findings suggest remarkable similarity in the pattern and heritability of NW across adult and adolescent smokers, and highlight the important role of NW in psychiatric comorbidity and the process of smoking cessation across both age groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.