ReviewBirth defects research. Part A, Clinical and molecular teratology2010
Understanding diabetic teratogenesis: where are we now and where are we going?
Review in Birth defects research. Part A, Clinical and molecular teratology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 100 citations in OpenAlex.
- Exploring the associations of overweight and obesity with pregnancy outcomes in type 1 and type 2 diabetes: An Australian retrospective cohort study.Journal of diabetes investigation · 2026Article
- Relationship between gestational diabetes and term infant hearing outcomes: a cross-sectional data linkage study.Pediatric research · 2026Article
- The Molecular Mechanism of Craniofacial Cartilage Deformity Induced by High Glucose in Zebrafish.Current issues in molecular biology · 2025Article
- Maternal Pre-Existing Diabetes: A Non-Inherited Risk Factor for Congenital Cardiopathies.International journal of molecular sciences · 2023Review
- Understanding the self-management experiences and support needs during pregnancy among women with pre-existing diabetes: a qualitative descriptive study.BMC pregnancy and childbirth · 2023Article
- Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure.WIREs mechanisms of disease · 2022Review
- Identification of immune-related biomarkers in embryos with neural tube defects via a bioinformatics analysis.Annals of translational medicine · 2022Article
- High glucose causes developmental abnormalities in neuroepithelial cysts with actin and HK1 distribution changes.Frontiers in cell and developmental biology · 2022Article
- Micronutrient imbalance and common phenotypes in neural tube defects.Genesis (New York, N.Y. : 2000) · 2021Review
- Impact of maternal hyperglycemia on cardiac development: Insights from animal models.Genesis (New York, N.Y. : 2000) · 2021Review
- Patient-Reported Benefits and Limitations of Mobile Health Technologies for Diabetes in Pregnancy: Protocol for a Scoping Review.JMIR research protocols · 2021Article
- Skeletal malformations and growth disturbances in fetuses of mild diabetic ratsBiomedica : revista del Instituto Nacional de Salud · 2021Article
- A Glimpse at the Size of the Fetal Liver-Is It Connected with the Evolution of Gestational Diabetes?International journal of molecular sciences · 2021Review
- Dysglycemia in Pregnancy and Maternal/Fetal Outcomes.Journal of women's health (2002) · 2021Article
- An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs).Expert opinion on drug metabolism & toxicology · 2020Review
- Maternal risk factors for the VACTERL association: A EUROCAT case-control study.Birth defects research · 2020Article
- Aberrant DNA methylation as a diagnostic biomarker of diabetic embryopathy.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Sociodemographic, health behavioral, and clinical risk factors for anotia/microtia in a population-based case-control study.International journal of pediatric otorhinolaryngology · 2019Article
- Identifying signals of potentially harmful medications in pregnancy: use of the double false discovery rate method to adjust for multiple testing.British journal of clinical pharmacology · 2019Article
- Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms.Birth defects research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Maternal pregestational diabetes (type 1 or type 2) poses an increased risk for a broad spectrum of birth defects. To our knowledge, this problem first came to the attention of the Teratology Society at the 14th Annual Meeting in Vancouver, B.C. in 1974, with a presentation by Lewis Holmes, "Etiologic heterogeneity of neural tube defects". Although advances in the control of diabetes in the decades since the discovery of insulin in the 1920's have reduced the risk for birth defects during diabetic pregnancy, the increasing incidence of diabetes among women of childbearing years indicates that this cause of birth defects is a growing public health concern. Major advances in understanding how a disease of maternal fuel metabolism can interfere with embryogenesis of multiple organ systems have been made in recent years. In this review, we trace the history of the study of diabetic teratogenesis and discuss a model in which tissue-specific developmental control genes are regulated at specific times in embryonic development by glucose metabolism. The major function of such genes is to suppress apoptosis, perhaps to preserve proliferative capability, and inhibit premature senescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.