ArticleJournal of muscle research and cell motility2010
Investigation of changes in skeletal muscle alpha-actin expression in normal and pathological human and mouse hearts.
Article in Journal of muscle research and cell motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- An extensive β1-adrenergic receptor gene signaling network regulates molecular remodeling in dilated cardiomyopathies.JCI insight · 2023Article
- Cardiac sarcomere mechanics in health and disease.Biophysical reviews · 2021Review
- Urocortin 2 Gene Transfer Improves Heart Function in Aged Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway.PloS one · 2020Article
- Urocortin 3 Gene Transfer Increases Function of the Failing Murine Heart.Human gene therapy · 2019Article
- Actin-associated proteins and cardiomyopathy-the 'unknown' beyond troponin and tropomyosin.Biophysical reviews · 2018Review
- Top-down Proteomics: Technology Advancements and Applications to Heart Diseases.Expert review of proteomics · 2016Review
- A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress.American journal of physiology. Heart and circulatory physiology · 2015Article
- Effective top-down LC/MS+ method for assessing actin isoforms as a potential cardiac disease marker.Analytical chemistry · 2015Article
- Adaptations of cytoarchitecture in human dilated cardiomyopathy.Biophysical reviews · 2015Article
- Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches.Proteomics. Clinical applications · 2014Article
- Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.Frontiers in physiology · 2014Review
- Tropomyosin isoform expression and phosphorylation in the human heart in health and disease.Journal of muscle research and cell motility · 2013Article
- Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.The Journal of biological chemistry · 2011Article
- How do mutations in contractile proteins cause the primary familial cardiomyopathies?Journal of cardiovascular translational research · 2011Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
We have developed a quantitative antibody-based assay to measure the content of skeletal muscle alpha-actin relative to cardiac alpha-actin. We found 21 +/- 2% skeletal muscle alpha-actin content in normal heart muscle of adult man and mouse. In end stage failing heart 53 +/- 5% of striated actin was skeletal muscle alpha-actin and in samples of inter-ventricular septum from patients with hypertrophic obstructive cardiomyopathy (HOCM) skeletal muscle alpha-actin was 72 +/- 2% of sarcomeric actin. Thin filaments containing actin isolated from normal and HOCM heart muscle were functionally indistinguishable when studied by quantitative in vitro motility assay. We also found elevated skeletal muscle alpha-actin (60 +/- 7%) in a mouse model of dilated cardiomyopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.