ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Serum complement C3 has a stronger association with insulin resistance than high sensitive C-reactive protein in non-diabetic Chinese.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- Maternal serum proteomic profiles of pregnant women with type 1 diabetes.Scientific reports · 2022Article
- MALDI-TOF MS Characterisation of the Serum Proteomic Profile in Insulin-Resistant Normal-Weight Individuals.Nutrients · 2021Article
- Biomarkers of subclinical atherosclerosis in patients with psoriatic arthritis.Open access rheumatology : research and reviews · 2019Review
- Interleukin-6 is a better metabolic biomarker than interleukin-18 in young healthy adults.Journal of physiology and biochemistry · 2015Article
- Serum complement C3 correlates with insulin resistance in never treated psoriatic arthritis patients.Clinical rheumatology · 2014Article
- Contribution of gender and body fat distribution to inflammatory marker concentrations in apparently healthy young adults.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare association of complement C3 (C3) and high sensitive C-reactive protein (hs-CRP) with insulin resistance. SUBJECTS: A total of 587 non-diabetic Chinese aged 20-80 years were recruited.
methodsComplement C3 and hs-CRP were measured by the rate nephelometry method and the particle enhanced immunoturbidimetric method, respectively, and their relationship to insulin resistance was assessed. Insulin resistance was defined as the upper quartile of HOMA2-IR.
resultsComplement C3 and hs-CRP were significantly higher in subjects with insulin resistance than those without. Complement C3 was the second strongest determinant of insulin in the study (β = 0.34, P < 0.001). By regression analysis, C3 was significantly associated with insulin resistance (OR = 3.78, P < 0.05), independent of waist circumference and other metabolic risk factors; however, hs-CRP was not. Receiver operating characteristic curve analysis indicated the best model predicting insulin resistance was one that included C3 and waist circumference (AUC = 0.741, P < 0.05).
conclusionCompared to hs-CRP, serum C3 might be a better inflammatory marker of insulin resistance in the non-diabetic Chinese population.
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