ArticleJournal of ophthalmology2010
Human genetics of diabetic retinopathy: current perspectives.
Article in Journal of ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
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Who cites it
25 citing papers in PubMed.
- Article
- Genome-wide association studies identify two novel loci conferring susceptibility to diabetic retinopathy in Japanese patients with type 2 diabetes.Human molecular genetics · 2021Article
- Single locus and haplotype association of ENPP1 gene variants with the development of retinopathy among type 2 diabetic patients.International ophthalmology · 2020Article
- Genetics of Diabetic Retinopathy.Current diabetes reports · 2019Review
- Unraveling the role of genetics in the pathogenesis of diabetic retinopathy.Eye (London, England) · 2019Review
- Oxidative Stress as the Main Target in Diabetic Retinopathy Pathophysiology.Journal of diabetes research · 2019Review
- The Association of CEP135 rs4865047 and NPY2R rs1902491 Single Nucleotide Polymorphisms (SNPs) with Rapid Progression of Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes Mellitus.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Whole exome sequencing identification of novel candidate genes in patients with proliferative diabetic retinopathy.Vision research · 2017Review
- Candidate gene studies of diabetic retinopathy in human.Molecular biology reports · 2016Review
- Genetic and epigenetic modifications in the pathogenesis of diabetic retinopathy: a molecular link to regulate gene expression.New frontiers in ophthalmology (London) · 2016Article
- Genetic components in diabetic retinopathy.Indian journal of ophthalmology · 2016Article
- Polymorphisms in the CTSH gene may influence the progression of diabetic retinopathy: a candidate-gene study in the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987).Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2015Article
- Gene set enrichment analysis of pathways and transcription factors associated with diabetic retinopathy using a microarray dataset.International journal of molecular medicine · 2015Article
- Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.Diabetologia · 2015Article
- C-reactive protein genetic variant is associated with diabetic retinopathy in Chinese patients with type 2 diabetes.BMC endocrine disorders · 2015Article
- The role of NOS2A -954G/C and vascular endothelial growth factor +936C/T polymorphisms in type 2 diabetes mellitus and diabetic nonproliferative retinopathy risk management.Therapeutics and clinical risk management · 2015Article
- Application of random forests methods to diabetic retinopathy classification analyses.PloS one · 2014Article
- Challenges in elucidating the genetics of diabetic retinopathy.JAMA ophthalmology · 2014Review
- Genome-wide association study in a Chinese population with diabetic retinopathy.Human molecular genetics · 2013Article
- Association of ELMO1 gene polymorphisms with diabetic nephropathy in Chinese population.Journal of endocrinological investigation · 2013Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic retinopathy (DR) is a most severe microvascular complication which, if left unchecked, can be sight-threatening. With the global prevalence of diabetes being relentlessly projected to rise to 438 million subjects by 2030, DR will undoubtedly pose a major public health concern. Efforts to unravel the human genetics of DR have been undertaken using the candidate gene and linkage approaches, while GWAS efforts are still lacking. Aside from evidence for a few genes including aldose reductase and vascular endothelial growth factor, the genetics of DR remain poorly elucidated. Nevertheless, the promise of impactful scientific discoveries may be realized if concerted and collaborative efforts are mounted to identify the genes for DR. Harnessing new genetic technologies and resources such as the upcoming 1000 Genomes Project will help advance this field of research, and potentially lead to a rich harvest of insights into the biological mechanisms underlying this debilitating complication.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.