Evidence map›Paper›PMID 20706626›Full record

Trial reportPLoS neglected tropical diseases2010

A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults.

Vianney Tricou, Nguyet Nguyen Minh, Toi Pham Van, Sue J Lee, Jeremy Farrar, Bridget Wills, Hien Tinh Tran, Cameron P Simmons

Erratum issued Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PLoS neglected tropical diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04334967 (Randomized Study to Evaluate the Safety and Antiviral Efficacy of Hydroxychloroquine in Patients With Newly Diagnosed COVID-19 Compared to Standard of Care Treatment), which is not on this map. Cited by 172 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 9 pooled it
7.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04334967 phase4suspendednot on this mapstarted 2020, after this paper: background citation

Randomized Study to Evaluate the Safety and Antiviral Efficacy of Hydroxychloroquine in Patients With Newly Diagnosed COVID-19 Compared to Standard of Care Treatment

TypeinterventionalSponsorProvidence Health & ServicesRan2020 to 2022Enrolled13ConditionsCOVID-19, Corona Virus Infection, SARS-CoV-2, 2019-nCoVArmsHydroxychloroquine, Vitamin C
3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 9 syntheses or guidelines pooled it, 324 citations in OpenAlex.

  1. Pooled it
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  7. Clinical evidence for repurposing chloroquine and hydroxychloroquine as antiviral agents: a systematic review.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020
    Pooled it
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  10. Trial
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  15. Lovastatin for the Treatment of Adult Patients With Dengue: A Randomized, Double-Blind, Placebo-Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Trial
  16. Chloroquine use improves dengue-related symptoms.Memorias do Instituto Oswaldo Cruz · 2013
    Trial
  17. Trial
  18. Effects of short-course oral corticosteroid therapy in early dengue infection in Vietnamese patients: a randomized, placebo-controlled trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2012
    Trial
  19. Trial
  20. Article

112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
  • Erratum issued
  • Erratum issued
5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Vianney TricouOxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam.
Nguyet Nguyen Minh
Toi Pham Van
Sue J Lee
Jeremy Farrar
Bridget Wills
Hien Tinh Tran
Cameron P Simmons
Hospital for Tropical Diseases · VNOxford University Clinical Research Unit · VNMahidol University · TH

Funding

Wellcome Trust 084368
6 · The paper itself

Abstract

backgroundThere is currently no licensed antiviral drug for treatment of dengue. Chloroquine (CQ) inhibits the replication of dengue virus (DENV) in vitro. METHODS AND

findingsA double-blind, randomized, placebo-controlled trial of CQ in 307 adults hospitalized for suspected DENV infection was conducted at the Hospital for Tropical Diseases (Ho Chi Minh City, Vietnam) between May 2007 and July 2008. Patients with illness histories of 72 hours or less were randomized to a 3-day course of CQ (n = 153) or placebo (n = 154). Laboratory-confirmation of DENV infection was made in 257 (84%) patients. The primary endpoints were time to resolution of DENV viraemia and time to resolution of DENV NS1 antigenaemia. In patients treated with CQ there was a trend toward a longer duration of DENV viraemia (hazard ratio (HR) = 0.80, 95% CI 0.62-1.05), but we did not find any difference for the time to resolution of NS1 antigenaemia (HR = 1.07, 95% CI 0.76-1.51). Interestingly, CQ was associated with a significant reduction in fever clearance time in the intention-to-treat population (HR = 1.37, 95% CI 1.08-1.74) but not in the per-protocol population. There was also a trend towards a lower incidence of dengue hemorrhagic fever (odds ratio = 0.60, PP 95% CI 0.34-1.04) in patients treated with CQ. Differences in levels of T cell activation or pro- or anti-inflammatory plasma cytokine concentrations between CQ- and placebo-treated patients did not explain the trend towards less dengue hemorrhagic fever in the CQ arm. CQ was associated with significantly more adverse events, primarily vomiting.

conclusionsCQ does not reduce the durations of viraemia and NS1 antigenaemia in dengue patients. Further trials, with appropriate endpoints, would be required to determine if CQ treatment has any clinical benefit in dengue.

trial registrationCurrent Controlled Trials number ISRCTN38002730.

Indexed as

AdolescentAdultAntigens, ViralAntiviral AgentsChloroquineDengueDouble-Blind MethodFemaleHumansMalePlacebosTime FactorsVietnamViral LoadViremiaYoung AdultAntigens, ViralAntiviral AgentsChloroquinePlacebos

Identifiers

PMID20706626
PMCPMC2919376
OpenAlexW2006539971

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.