ArticleAmerican journal of respiratory cell and molecular biology2011
Human influenza is more effective than avian influenza at antiviral suppression in airway cells.
Article in American journal of respiratory cell and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 44 citations in OpenAlex.
- Advancing influenza virus treatment:Materials today. Bio · 2025Article
- Modulation of cytokeratin and cytokine/chemokine expression following influenza virus infection of differentiated human tonsillar epithelial cells.Journal of virology · 2025Article
- Production of antiviral "OP7 chimera" defective interfering particles free of infectious virus.Applied microbiology and biotechnology · 2024Article
- Differential interferon responses to influenza A and B viruses in primary ferret respiratory epithelial cells.Journal of virology · 2024Article
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- Comparison of genome replication fidelity between SARS-CoV-2 and influenza A virus in cell culture.Scientific reports · 2023Article
- A Game of Infection - Song of Respiratory Viruses and Interferons.Frontiers in cellular and infection microbiology · 2022Review
- Comprehensive Transcriptomic Analysis Identifies Novel Antiviral Factors Against Influenza A Virus Infection.Frontiers in immunology · 2021Article
- Article
- Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics.Respiratory research · 2018Article
- Influenza Virus: A Master Tactician in Innate Immune Evasion and Novel Therapeutic Interventions.Frontiers in immunology · 2018Review
- MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD.JCI insight · 2017Article
- Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.eLife · 2017Article
- Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses.Respiratory research · 2016Article
- Article
- Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.JCI insight · 2016Article
- Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma.Mediators of inflammation · 2015Article
- Article
- The placental protein syncytin-1 impairs antiviral responses and exaggerates inflammatory responses to influenza.PloS one · 2015Article
- Differential cellular gene expression in duck trachea infected with a highly or low pathogenic H5N1 avian influenza virus.Virology journal · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airway epithelial cells are the initial site of infection with influenza viruses. The innate immune responses of airway epithelial cells to infection are important in limiting virus replication and spread. However, relatively little is known about the importance of this innate antiviral response to infection. Avian influenza viruses are a potential source of future pandemics; therefore, it is critical to examine the effectiveness of the host antiviral system to different influenza viruses. We used a human influenza (H3N2) and a low-pathogenic avian influenza (H11N9) to assess and compare the antiviral responses of Calu-3 cells. After infection, H3N2 replicated more effectively than the H11N9 in Calu-3 cells. This was not due to differential expression of sialic acid residues on Calu-3 cells, but was attributed to the interference of host antiviral responses by H3N2. H3N2 induced a delayed antiviral signaling and impaired type I and type III IFN induction compared with the H11N9. The gene encoding for nonstructural (NS) 1 protein was transfected into the bronchial epithelial cells (BECs), and the H3N2 NS1 induced a greater inhibition of antiviral responses compared with the H11N9 NS1. Although the low-pathogenic avian influenza virus was capable of infecting BECs, the human influenza virus replicated more effectively than avian influenza virus in BECs, and this was due to a differential ability of the two NS1 proteins to inhibit antiviral responses. This suggests that the subversion of human antiviral responses may be an important requirement for influenza viruses to adapt to the human host and cause disease.
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