ArticleMolecular human reproduction2011
Chorionic gonadotrophin regulates CXCR4 expression in human endometrium via E-series prostanoid receptor 2 signalling to PI3K-ERK1/2: implications for fetal-maternal crosstalk for embryo implantation.
Article in Molecular human reproduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Associations Between Follicular Fluid Biomarkers and IVF/ICSI Outcomes in Normo-Ovulatory Women-A Systematic Review.Biomolecules · 2025Pooled it
- Does Intrauterine Injection of hCG Improve IVF Outcome? A Systematic Review and a Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Epidemiology, Risk Factors, and Management of Pregnancy-Related Chronic Back Pain.Current pain and headache reports · 2026Review
- Fatty Acid Metabolism Disruptions: A Subtle yet Critical Factor in Adverse Pregnancy Outcomes.International journal of biological sciences · 2024Review
- Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation.JCI insight · 2023Article
- Research on the Mechanism of Asperosaponin VI for Treating Recurrent Spontaneous Abortion by Bioinformatics Analysis and Experimental Validation.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Transcriptomic analysis shows that surgical treatment is likely to influence the endometrial receptivity of patients with stage III/IV endometriosis.Frontiers in endocrinology · 2022Article
- CXCL12 May Drive Inflammatory Potential in the Ovine Corpus Luteum During Implantation.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation.Reproductive biology and endocrinology : RB&E · 2018Review
- In the ovine pituitary, CXCR4 is localized in gonadotropes and somatotropes and increases with elevated serum progesterone.Domestic animal endocrinology · 2018Article
- EGFR expression is associated with cytoplasmic staining of CXCR4 and predicts poor prognosis in triple-negative breast carcinomas.Oncology letters · 2017Article
- The PI3K/Akt signaling pathway exerts effects on the implantation of mouse embryos by regulating the expression of RhoA.International journal of molecular medicine · 2014Article
- The regulation of inflammatory pathways and infectious disease of the cervix by seminal fluid.Pathology research international · 2014Review
- Article
- Natural selection in utero induced by mass layoffs: the hCG evidence.Evolutionary applications · 2012Article
- Expression of maspin in the early pregnant mouse endometrium and its role during embryonic implantation.Comparative medicine · 2012Article
- Regulation of inflammatory pathways in cancer and infectious disease of the cervix.Scientifica · 2012Review
- Extragonadal actions of chorionic gonadotropin.Reviews in endocrine & metabolic disorders · 2011Review
- Contraceptive vaccines targeting factors involved in establishment of pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Review
- Hormonal evidence supports the theory of selection in utero.American journal of human biology : the official journal of the Human Biology CouncilArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Murine knock-out models and blastocyst co-culture studies have identified prostaglandin-endoperoxide synthase (PTGS) 2, prostaglandin (PG) E receptor 2 (PTGER2) and the chemokine receptor CXCR4 as important regulators of early pregnancy events. In vitro studies and studies in non-human primates have shown that these proteins are regulated in the endometrium by the early embryonic signal, chorionic gonadotrophin (CG). Here we show that expressions of PTGER2 and CXCR4 are elevated during the mid-secretory phase of the menstrual cycle and decidua of early pregnancy in humans. Using first trimester decidua explants, we show that CG induces expression of PTGS2 and biosynthesis of PGE₂, and expression of PTGER2. Subsequently, PGE₂via PTGER2 induces expression of CXCR4. Using an in vitro model system of Ishikawa endometrial epithelial cells stably expressing PTGER2 and human first trimester decidua explants, we demonstrate that CXCR4 expression is regulated by PTGER2 via the epidermal growth factor receptor (EGFR)-phosphatidylinositol-3-kinase (PI3K)-extracellular signal-regulated kinase (ERK1/2) pathway.Taken together, our data suggest that early embryonic signals may regulate fetal-maternal crosstalk in the human endometrium by inducing CXCR4 expression via the PGE₂-PTGER2-mediated induction of the EGFR, PI3K and ERK1/2 pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.